Abstract
Primary adenocarcinoma of the esophagus is rare in Japan and, in most cases, arises from Barrett's esophagus epithelium. A 72-year-old man reporting heartburn and dysphagia and preoperatively diagnosed with adenosquamous carcinoma arising from Barrett's esophagus underwent thoracic esophagectomy and lymph node dissection in curative resection. Pathological diagnosis of the resected specimen showed adenosquamous carcinoma (coexistent adenocarcinoma and squamous cell carcinoma) invasive to the submucosal layer; metastasis was found in regional lymph nodes. Pathological staging was pT1bN1M0, stage II. Unfortunately, the man died of liver and lung metastasis 17 months postoperatively. To our knowledge, this rare case is only the fifth reported in the English literature on adenosquamous carcinoma arising from Barrett's esophagus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barrett NR. Chronic ulcer of the oesophagus and oesophagitis. Br J Surg 1950; 38: 175–82.
Noguchi T, Takeno S, Uchida Y, Shimoda H, Daa T, Yokoyama S. Clinicopathological and immunohistochemical study of cancer arising from Barrett's esophagus. Oncol Rep 1999; 6: 1293–7.
Yang PC, Davis S. Incidence of cancer of the esophagus in the US by histologic type. Cancer 1988; 61: 612–7.
Hamilton SR, Smith RR. The relationship between columnar epithelial dysplasia and invasive adenocarcinoma arising in Barrett's esophagus. Am J Clin Pathol 1987; 87: 301–12.
Sobin LH, Wittekind CH. UICC TNM Classification of Malignant Tumours. 5th ed. New York: Wiley-Liss, 1997: 59–62.
Tytgat GNJ, Hameeteman W. The neoplastic potential of columnar-lined (Barrett's) esophagus. World J Surg 1992; 16: 308–12.
Smith RR, Hamilton SR, Boitnott JK, Rogers EL. The spectrum of carcinoma arising in Barrett's esophagus: a clinicopathologic study of 26 patients. Am J Surg Pathol 1984; 8: 563–73.
Pera M, Brito MJ, Poulson R, Riera E, Grande L, Hanby A, Wright NA. Duodenal-content reflux esophagitis induces the development of glandular metaplasia and adenosquamous carcinoma in rats. Carcinogenesis 2000; 21: 1587–91.
Miwa K, Sahara H, Segawa M, Kinami S, Sato T, Miyazaki I, et al. Reflux of duodenal or gastro-duodenal contents induces esophageal carcinoma in rats. Int J Cancer 1996; 67: 269–74.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Noguchi, T., Uchida, Y., Fumoto, S. et al. Adenosquamous carcinoma arising in Barrett's esophagus. Jpn J Thorac Cardiovasc Surg 50, 537–540 (2002). https://doi.org/10.1007/BF02913171
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02913171