Abstract
The effect of five 3-(2-alkoxyphenylcarbamoyloxy)chinuclidium chlorides (alkoxy = butoxy-octyloxy) on survival of a wild-type strain and repair-deficient strains ofChlamydomonas reinhardtii was studied. There was a direct relationship with increased toxic effects in the algal strains as a function of the elongation of the alkyl chain of the alkoxy substituents of the phenylcarbamate acid derivatives. Repairdeficient strains were more sensitive than the wild-type strain. The recombination-deficient strain uvs10 expressed the highest sensitivity to the test agents. This suggests that a gene responsible for recombination repair is involved in an important role in DNA repair of damages induced inC. reinhardtii by the phenylcarbamic esters.
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Ames, B.N., McCann, J., Yamasaki, E.: Methods for detecting carcinogens and mutagens with theSalmonella/mammalian—microsome mutagenicity test.—Mutat. Res.31: 347–364, 1975.
Beneš, L., Borovanský, A., Kopáčová, L.: Basiche trans- und cis-Cyklohexylester Substituierter Alkoxycarbanilsäuren.—Arch. Pharm. (Weinheim)305:648–654, 1972.
Brendel, M., Ruhland, A.: Relationship between functionality and genetic toxicology of selected DNA-damaging agents.—Mutat. Res.133: 51–85, 1984.
Čižmárik, J., Trupl, J., Pešák, M.: A correlation between antimicrobial activity toStaphylococcus aureus and selected physico-chemical parameters in the series of hydrochlorides of piperidinoethylesters of alkoxysubstituted phenyl-carbamic acids.—Českoslov. Farm.36: 345–348, 1987.
Csöllei, J.: 1-methyl-2-(2-aminoethoxy)ethylesters of alkoxysubstituted phenylcarbamic acids and their effects on photosynthesis inhibition.—Českoslov. Farm.42: 265–267, 1993.
Csöllei, J., Beneš, L., Borovanský, A., Švec, P., Bederová, E., Kozlovský, J.: Studies of the local anaesthetics LXXXV. N-alkyl-4-piperidyl esters ofo-andm-alkoxycarbanilic acids with local anaesthetic and antiarrhythmic effects.—Českoslov. Farm.35: 299–302, 1986.
Fleer, R., Brendel, M.: Toxicity, interstrand crosslinks, and DNA fragmentation induced by “activated” cyclophosphamide in yeast. Comparative studies on 4-hydroxyperoxy-cyclophosphamide, its monofunctional analogon acrolein, phosphamide mustard, and nor-nitrogen mustard.—Chem. Biol. Interact.39: 1–15, 1982.
Green, M.H.L., Muriel, W.J.: Mutagen using trp+ reversion inEscherichia coli.—Mutat. Res.38: 3–32, 1976.
Gregáň, F., Ďurinda, J., Račanská, E., Zámocká, J.: Synthesis and local anaesthetic activities of 3-(2-alkoxyphenylcarbamoyloxy)-chinuclidinium chlorides.—Pharmazie48: 465–466, 1993b.
Gregáň, F., Kettmann, V., Novomeský, P., Račanská, E., Švec, P.: Synthesis and local anaesthetic activity of some derivatives of N,N-diethyl-2-(2-alkoxyphenylcarbamoyloxy)bornan-3-ylmethylamonium chlorides.—Farmaco48: 375–385, 1993a.
Gregáň, F., Novomeský, P., Račanská, E., Kettmann, V.: Synthesis and local anaesthetic activity of some derivatives of N,N-dimethyl-2-(2-alkoxyphenylcarbamoyloxy)-1,1-dimethylethylamonium chlorides.—Farmaco47: 327–334, 1992.
Král’ová, K., Šeršeň, F., Čižmárik, J.: Inhibitory effect of piperidinoethylesters of alkoxyphenylcarbamic acids on photosynthesis.—Gen. Physiol. Biophys.11: 261–267, 1992a.
Král’ová, K., Šeršeň, F., Csöllei, J.: Inhibitory effect of some esters of 2- and 3-substituted alkoxyphenylcarbamic acids on photosynthetic characteristics.—Biol. Plant.34: 253–258, 1992b.
Mitterhauszerová, L., Král’ová, K., Šeršeň, F., Czöllei, J., Krempaská, E. Influence of dibasic local anaesthetics on photosynthesis of green algae and plants.—Českoslov. Farm.40: 209–213, 1991a.
Mitterhauszerová, L., Král’ová, K., Šeršeň, F., Blanáriková, V., Czöllei, J.: Effects of substituted aryloxyaminopropanols on photosynthesis and photosynthesing organisms.—Physiol. Biophys.10: 309–319, 1991b.
Starr, R.C.: Algal cultures—sources and methods of cultivation.—Methods Enzymol.23: 29–53, 1971.
Vlček, D., Podstavková, S., Miadoková, E., Adams, G.M.W., Small, G.D.: General characteristics, molecular and genetic analysis of two new UV-sensitive mutants ofChlamydomonas reinhardtii.—Mutat. Res.183: 169–175, 1987.
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Miadoková, E., Šepaková, K., Podstavková, S. et al. Effects of 3-(2-alkoxyphenylcarbamoyloxy)chinuclidium chlorides on repair-deficient strains ofChlamydomonas reinhardtii . Biol Plant 37, 15–19 (1995). https://doi.org/10.1007/BF02912992
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DOI: https://doi.org/10.1007/BF02912992