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A study of thyroid status in hyperemesis gravidarum

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Abstract

Study was undertaken to assess thyroid status in hyperemesis gravidarum. 150 women pregnant with <20 weeks of gestation were selected randomly and out of these 100 women presenting with hyperemesis formed study group while 50 normal pregnant women served as controls. 53% of hyperemetic pregnant women were primigravidae and 82% of pregnant women presented with vomiting at less than 12 weeks of gestation. Statistically significant, 22% of hyperemetic women had increased serum T3 levels while T4 levels were increased in 67% of women in study group as compared to 8% and 16% respectively in control group. TSH levels were decreased in 18% of hyperemetic women as compared to 8% in control group with decrease in mean TSH level statistically significant. 22% of hyperemetic women had electrolyte disturbances and 7% were ketonuric. In clinically euthyroid women, biochemically altered thyroid function can attribute to vomiting and its prolongation to second trimester

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References

  1. Bennet T, Kotelchuck M, Cox C, Tucker M, Nadeau D. Pregnancy-associated hospitalizations in the United States in 1991 and 1992: a comprehensive view of maternal morbidity. Am J Obstet Gynecol 1998; 178: 346–54.

    Article  Google Scholar 

  2. Dutta D C Vomiting in pregnancy Dutta D C, Textbook of Obstetrics, 6th Edn. Calcutta, Hiralal Konar, New Central Book Agency (P) Ltd, India 2004; 155–8.

    Google Scholar 

  3. Baljit JL, Hyperemesis gravidarum: Epidemiologic findings from a large cohort. Am J Obstet Gynecol 2005; 193, 811–4.

    Article  Google Scholar 

  4. Verberg M F G, Gillott D J, Al-Fardan N, Grudzinskas J G. Hyperemesis gravidarum, a literature review. Human Reproduction Update 2005; 11 (5): 527–39.

    Article  PubMed  CAS  Google Scholar 

  5. Goodwin TM, Montoro M, Mestman JH, Pekary AE, Hershman JM. The role of chorionic gonadotrophin in transient hyperthyroidism of hyperemesin gravidarum. J Clin Endocrinol Metab 1992; 75: 1333–7.

    Article  PubMed  CAS  Google Scholar 

  6. Aroya ZB, Lurie S, Segal D, Hallak M et al. Association of nausea and vomiting in pregnancy with lower body mass index. Eur J Obstet & Gynecol Reprod Bio 2005; 118 (2): 196–8.

    Article  Google Scholar 

  7. Panesar NS, Li CY, Roger MS. Are thyroid hormones or HCG responsible for hyperemesis gravidarum? A matched paired study in pregnant Chinese women. Acta Obstet Gynecol Scand 2001; 80: 519–24.

    Article  PubMed  CAS  Google Scholar 

  8. Kimura M, Amino N, Tanaki H et al. Gestational thyrotoxicosis and hyperemesis gravidarum: possible role of hCG with higher stimulating activity. Clin Endocrinol 1993; 38: 345–50.

    Article  CAS  Google Scholar 

  9. Tan JYL, Loh KC, Yeo GSH, Chee YC. Transient hyperthyroidism of hyperemesis gravidarum. Br J Obstet Gynecol 2002; 109: 683–8.

    Google Scholar 

  10. Fantz CR, Jack SD, Ladenson JH, Gronowski MA Thyroid function during pregnancy. Clinical Chemistry 1999; 45: 2250–58.

    PubMed  CAS  Google Scholar 

  11. Stockigt AC. Free thyroid hormone measurement. Endocrinol Clin North Am 2001; 30: 265–89.

    Article  CAS  Google Scholar 

  12. Cunningham FG, Gant NF, Leveno KJ, Gilstrap LC, Hauth JC, Wenstrom KD, The placental hormones. Seils A, Susan RN, Davis K, Williams Obstetrics; 21to Edn. New York New Delhi, McGraw Hill Medical Publishing Division 2001; 109–28.

    Google Scholar 

  13. Ganguli G, Mukherjee K, Dayal M, Misra A, Verma M, Mehratora R, A study of thyroid function in hyperemesis gravidarum. J Obstet Gynecol Ind 1993; 43: 48–51.

    Google Scholar 

  14. Bashiri A, Neumann L, Maymon E, Katz M, Hyperemesis Gravidarum: epidemiological features, complications and outcome. Eur J Obstet Gynecol Reprod Bio 1995; 63 (2): 135–8.

    Article  CAS  Google Scholar 

  15. Tsang IS, Katz VL, Wells SD. Maternal and fetal outcomes in hyperemesis gravidarum. Int J Obstet Gynecol 1996; 55 (3): 231–5.

    Article  CAS  Google Scholar 

  16. Wilson R, Mckillop JH, McLean M, Thyroid function tests are rarely abnormal in patients with severe hyperemesis gravidarum. Clin Endocrinol 1992; 37: 331–4

    Article  CAS  Google Scholar 

  17. Kol S, Karnieli E, Kraiem Z, Eldor JI, Lightman A, Shalom SI Thyroid function in early normal pregnancy: transient suppression of thyroid stimulating hormone and stimulation of triiodothyronine. Gynecol Obstet Invest 1996; 42: 227–9.

    Article  PubMed  CAS  Google Scholar 

  18. Appierot U, Subrizi DA, Minozzi M, Unfer V Nausea, vomiting and thyroid function before and after induced abortion in normal pregnancy. Clin Exp Obstet Gynecol 1996; 23 (1): 18–20.

    Google Scholar 

  19. Sud SS, Huria Anju, Goel Poonam. Hyperthyroidism in pregnancy. Obs and Gynae Today 2005; 4: 200–203.

    Google Scholar 

  20. Price A, Davies R, Heller SR, Milford-Ward A, Weetman AP Asian women are at increased risk of gestational thyrotoxicosis. J Clin Endocrinol Metab 1996; 81 (3): 1160–63

    Article  PubMed  CAS  Google Scholar 

  21. Broussard C, Richter J. Nausea and vomiting of pregnancy. Gasteroenterol Clin North Am 1998; 27: 123–51.

    Article  CAS  Google Scholar 

  22. Rees JH, Ginsberg L, Schapira AH, Two pregnant women with vomiting and fits. Am J Obstet Gynecol 1993; 177 (6): 1539–40.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics And Gynaecology, Dayanand Medical College and Hospital, 20-B, Rishi Nagar, 141001, Ludhiana, India

    Bhupinder Kaur Gill, Promila Jindal, Shweta Tiwari, Namrata Sharma & Anupama Goel

  2. Department of Microbiology, Dayanand Medical College and Hospital, 20-B, Rishi Nagar, 141001, Ludhiana, India

    Raj Kumar

Authors
  1. Bhupinder Kaur Gill
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  2. Promila Jindal
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  3. Raj Kumar
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  4. Shweta Tiwari
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  5. Namrata Sharma
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  6. Anupama Goel
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Corresponding author

Correspondence to Promila Jindal.

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Gill, B.K., Jindal, P., Kumar, R. et al. A study of thyroid status in hyperemesis gravidarum. Indian J Clin Biochem 22, 148–151 (2007). https://doi.org/10.1007/BF02912900

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