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Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies

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Abstract

Rats fed with hypercholesterolemic diet showed a significant increase in serum total—cholesterol, liver homogenate total-cholesterol, HDL-cholesterol and changed LDL-cholesterol, and HDL/LDL ratio in comparison to control. Flaxseedchutney (FC) supplemented diet (15%, w/w) was found to be more effective in restoring lipid profile changes in rats fed with cholesterol, (1.0%). The activities of serum marker enzymes glutamate oxaloacetate transminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) were elevated significantly in carbon tetrachloride induced rats. Administration of flaxseedchutney (15%, w/w) resulted in depletion of serum marker enzymes and exhibited recoupment thus showing significant hepatoprotective effect. It was observed that flaxseedchutney supplemented diet could lower the serum cholesterol and as a potential source of antioxidants it could exert protection against hepatotoxic damage induced by carbon tetrachloride (CCl4) in rats.

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Authors and Affiliations

  1. Department of Studies and Research in Biochemistry and Food Technology, P.G. Centre-Kuvempu University, 577 002, Davangere, India

    K. A. Faseehuddin Shakir & Basavaraj Madhusudhan

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  1. K. A. Faseehuddin Shakir
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  2. Basavaraj Madhusudhan
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Correspondence to Basavaraj Madhusudhan.

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Shakir, K.A.F., Madhusudhan, B. Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies. Indian J Clin Biochem 22, 117–121 (2007). https://doi.org/10.1007/BF02912893

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