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Glomerular changes in acute renal allograft rejection in the dog

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Virchows Archiv B

Summary

Glomerular involvements during acute rejection of canine renal allografts were studied by immunofluorescence, light, and electron microscopy.

The immunofluorescence disclosed diffuse glomerular localizations of IgG and IgM with a granular or linear pattern in considerable numbers of grafts examined at day 3, 5, and 7 after transplantation. In these grafts, electron microscopy revealed splitting of the glomerular basement membrane (GBM) with subendothelial deposits resembling those described in human cases, which in turn resulted in endothelial exfoliation and finally in thrombotic lesions. In contrast, GBM alterations were minimal in the remaining grafts which showed only focal glomerular fluorescence, suggesting a significant role of humoral antibodies in the initiation of the GBM changes.

A progressive glomerular hypercellularity due largely to accumulation of monocytes was seen regardless of the immunofluorescence findings. However, in the fluorescence positive glomeruli, the migrant cells were often adherent to the GBM, exhibiting characteristic behaviors similar to those observed in Masugi nephritis.

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Authors and Affiliations

  1. Department of Pathology and Surgery, School of Medicine, Chiba University, Chiba, Japan

    Yoichiro Kondo, Takao Okamura, Hiroshi Nishijima, Ko Okumura, Naondo Suzuki & Yoji Iwasaki

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  1. Yoichiro Kondo
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  2. Takao Okamura
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  3. Hiroshi Nishijima
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  4. Ko Okumura
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  5. Naondo Suzuki
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Kondo, Y., Okamura, T., Nishijima, H. et al. Glomerular changes in acute renal allograft rejection in the dog. Virchows Arch. B Cell Path. 17, 63–78 (1975). https://doi.org/10.1007/BF02912836

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  • DOI: https://doi.org/10.1007/BF02912836

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