Abstract
The density of dendritic cells (DC) and macrophages (Mϕ) in tissue specimens of gastric carcinoma (GC n=65) was investigated by ABC immunohistochemical method using anti-S100 protein and anti-lysozyme antibodies, and was compared with that in gastric ulcer (GU n=19), chronic atrophic gastritis (CAG n=28) and normal gastric mucosa (NGM n=15). The mean density if DC (cells/mm2) in GC (15.0 was significantly higher than that in NGM (3.8) and GU (8.3), but was remarkably lower when compared to that in CAG (29.5) (P<0.01). Statistically significant difference in the population density of DC was observed between well- and poorly-differentiated GC (P<0.01). With their unique dendritic processes, DC were mainly concentrated within dense lymphoid infiltrates or in the T-area of reactive lymphoid follicles and were interspersed among the tumor cells. In contrast, Mϕ were present around the necrotic foci and were rarely seen within the non-necrotic neoplastic tissues. These data suggest that DC, which differ in morphology, distribution, number and function form Mϕ may be more directly involved in the host immune reaction against tumor by acting as antigen presenting cells.
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References
Favara BE, et al. Histocytosis X. Hum Pathol 1983; 14:663.
Poulter LW. The involvement of dendritic cells in chronic inflammatory disease. Scand J Immunol 1985; 21:401.
Inaba K, et al. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc Natl Acad Sci USA 1983; 80:6041.
Steinman RM, et al. Dendritic cells are principal. stimulators of the primary mixed leukocyte reaction in mice. J Exp Med 1983; 157:613.
Watanabe S, et al. Immunohistochemical study with monoclonal antibodies on immune response in human lung cancers. Cancer Res 1983; 45:5883.
Furukawa T, et al. T-zone histocytes in adenocarcinoma of the lung in relation to postoperative prognosis. Cancer 1985; 56:2651.
Hammar S, et al. The widespread distribution of Langerhans cells in pathologic tissues: An ultrastructural and immunohistochemical study. Hum Pathol 1986; 17:894.
McArdle JP, Muller HK. Quantitative assessment of Langerhans cells in human cervical intraepithelial neoplasia and wart virus infection. Am J Obstet Gynecol 1986; 154:509.
Meissner K, et al. Quantitative analysis of T6-positive Langerhans cells in human skin cancers. Virchows Arch (Pathol Anat) 1986; 410: 57.
Tsujitani S, et al. Langerhans cells and prognosis in patients with gastric carcinoma. Cancer 1987; 59:501.
Vera-Sempere FJ, et al. S-100 protein positive cells in nasopharyngeal carcinoma (NPC): Absence of prognostic significance. Virchows Arch (Pathol Anat) 1987; 411:233.
Mori M, et al. Prognostic value of immunohistochemically identified CEA, SC, AFP and S-100 protein-positive cells in gastric carcinoma. Cancer 1988; 62:534.
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Jian, H., Huaide, H., Qingbi, P. et al. Immunohistochemical study on S100 protein-positive dendritic cells in patients with gastric carcinoma. Chinese Journal of Cancer Research 2, 54–58 (1990). https://doi.org/10.1007/BF02912251
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DOI: https://doi.org/10.1007/BF02912251