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Studies on the anti-inflammatory activity ofAralia continentalis (III)

Anti-inflammatory activity of (−)-kaur-16-en-19-oic acid

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Abstract

Besides (−)-pimara-8(14), 15-dien-19-oic acid [I] which had already heen isolated as an active anti-inflammatory principle ofAralia continentalis, (−)-kaur-16-en-19-oic acid [II] was separated as another active component of the plant, by tracing albumin stabilizing activity. IC50 of [II] for the protein stabilizing activity was 0.026 mg/3 ml, when those of [I] and phenylbutazone were 0.032 and 0.32 mg/3 ml, respectively. Being investigated employing carrageenin-induced edema test in rat hind paw, the anti-inflammatory activity of [II] administered s.c. was slightly lower than that of phenylbutazone, whereas the activity of [II] administered p.o. was three times greater than that of phenylbutazone. These results of [II] were contrary to those of [I] in the aspect of administration routes.

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Authors and Affiliations

  1. Natural Products Research Institute, Seoul National University, 110, Seoul, Korea

    Byung Hoon Han, Eun Rhan Woo, Myung Hwan Park & Yong Nam Han

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  1. Byung Hoon Han
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  2. Eun Rhan Woo
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  3. Myung Hwan Park
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  4. Yong Nam Han
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Han, B.H., Woo, E.R., Park, M.H. et al. Studies on the anti-inflammatory activity ofAralia continentalis (III). Arch. Pharm. Res. 8, 59–65 (1985). https://doi.org/10.1007/BF02912223

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  • DOI: https://doi.org/10.1007/BF02912223

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