Skip to main content

Advertisement

SpringerLink
Log in

Osteoporosis in a boy with hypogonadotropic hypogonadism

  • Original Articles
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Summary

We describe a 16-year-old boy with idiopathic hypogonadotropic hypogonadism associated with osteoporosis. Osteoporotic lesions of the hands, skull and spine were shown by routine radiography. Single-photon absorptiometry at the distal radius confirmed a significant reduction of bone mineral density. The parathyroid hormone-vitamin D axis and calcitonin secretion showed no derangement. Reduced bone mineral density in association with relatively elevated levels of serum osteocalcin and alkaline phosphatase suggested an increased bone turnover (so-called high-turnover osteoporosis). Tetosterone therapy for 3 months significantly increased the radial bone mineral density.

This case illustrates that testosterone deficiency during puberty seems to alter the bone mineral status, impairing bone mineralization and bone remodeling.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Riggs B.L. and Melton L.J. III: Involutional osteoporosis. N. Engl. J. Med. 314, 1676–1686, 1986.

    PubMed  CAS  Google Scholar 

  2. Johnston Jr. C.C., Hui S.L., Witt R.M., et al: Early menopausal changes in bone mass and sex steroids. J. Clin. Endocrinol. Metab. 61, 905–911, 1985.

    PubMed  CAS  Google Scholar 

  3. Drinkwater B.L., Nilson K., Chesnut III C.H., st al: Bone mineral content of amenorrheic and eumenorrheic athletes. N. Engl. J. Med. 311, 277–81, 1984.

    PubMed  CAS  Google Scholar 

  4. Seeman E., Melton L.J. III, O'Fallon W.M., et al: Risk factors for spinal osteoporosis in men. Am. J. Med. 75, 977–983, 1983.

    Article  PubMed  CAS  Google Scholar 

  5. DiGeorge AM. Hypogonadotropic hypogonadism in the male. In: Nelson Textbook of Pediatrics, 13th edition, (Behrman R.E. and Vaughan V.C. III eds.), WB Saunders Company, Philadelphia, pp. 1234–1235, 1987.

    Google Scholar 

  6. Johanson J.S., Giwercman A., Hartwell D., et al: Serum bone Gla-protein as a marker of bone growth in children and adolescents: Correlation with age, height, serum insulin-like growth factor I, and serum testosterone. J. Clin. Endocrinol. Metab. 67, 273–278, 1988.

    Google Scholar 

  7. Yamamoto H., Arai T., Masuda K., et al: Serum osteocalcin during growth in children. Igakunoayumi 139, 1045–1046, 1986. (English abstr.)

    Google Scholar 

  8. Arisaka O., Arisaka M., Shimizu T., et al: Primary hyperparathyroidism. Clin. Pediatr. 24, 347–50, 1985.

    Article  CAS  Google Scholar 

  9. Aurbach G.D., Marx S.J. and Spiegel A.M.: Control of bone formation and resorption. In: William's Textbook of Endocrinology, 7th edition, (Wilson J.D. and Foster D.W. eds.), WB Saunders Company, Philadelphia, pp. 1223–1226, 1985.

    Google Scholar 

  10. Shore R.M., Chesney R.W., Mazess R., et al: Bone mineral status in growth hormone deficiency. J. Pediatr. 96, 393–396, 1980.

    Article  PubMed  CAS  Google Scholar 

  11. Krabbe S., Transbol I. and Christiansen C.: Bone mineral homeostasis, bone growth, and mineralization dring years of pubertal growth; a unifying concept. Arch. Dis. Chid. 57, 359–363, 1982.

    CAS  Google Scholar 

  12. Aloia J.F., Vaswani A.N., Yeh J.K., et al.: Premenopausal bone mass is related to physical activity. Arch. Inter. Med. 148, 121–123, 1988.

    Article  CAS  Google Scholar 

  13. Rigotti, N.A., Nussbaum S.R., Herzog D.B., et al.: Osteoporosis in women with anorexia nervosa. N. Engl. J. Med. 311, 1601–1606, 1984.

    PubMed  CAS  Google Scholar 

  14. Foresta C., Ruzza R., Guarneri G.. et al.: Testosterone and bone loss in Klinefelter syndrome. Horm. Metabol. Res. 15, 56–57, 1983.

    CAS  Google Scholar 

  15. Ruzza C.F., Mioni R., Guarneri G., et al.: Osteoporosis and decline of gonadal function in the elderly male. Hormone Res. 19, 18–22, 1984.

    Article  PubMed  Google Scholar 

  16. Greenspan S.L., Neer R.M., Ridgway E.C., et al.: Osteoporosis in men with hyperprolactinemic hypogonadism. Ann. Inter. Med. 104, 777–782, 1986.

    CAS  Google Scholar 

  17. Finkelstein J.S., Klibaski A., Neer M., et al: Osteoporosis in men with idiopathic hypogonadotropic hypogonadism. Ann. Inter. Med. 106, 354–361, 1987.

    CAS  Google Scholar 

  18. Arisaka O., Arisaka M., Hosaka A., et al: Bone mineral status in hypopituitarism. Am. J. Dis. Child. 143, 272–273, 1989.

    PubMed  CAS  Google Scholar 

  19. Arisaka O., Arisaka M., Hosaka A., et al: Increase in bone density during testosterone therapy in adolescent hypogonadism. Eur. J. Pediatr. 148, 579, 1989.

    Article  PubMed  CAS  Google Scholar 

  20. Gilsanz V., Gibbens D.T., Roe T.F., et al: Vertebral bone density in children: Effect of puberty. Radiology 166, 847–850, 1988.

    PubMed  CAS  Google Scholar 

  21. Chesney R.W. and Shore R.M.: The noninvasive determination of bone mineral content by photon acsorptiometry. Am. J. Dis. Child. 136, 578–580, 1982.

    PubMed  CAS  Google Scholar 

  22. Krabbe S., Hummer L. and Christiansen C.: Longitudinal study of calcium metabolism in male puberty. II Relationship between mineralization and serum testosterone. Acta. Paediatr. Scand. 73, 578–580, 1982.

    Google Scholar 

  23. Francis R.M., Peacock M., Aaron J.F., et al: Osteoporosis in hypogonadal men: role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption, and low bone fromation. Bone 7, 261–268, 1986.

    Article  PubMed  CAS  Google Scholar 

  24. Finkelstein J., Klibanski A., Neer M., et al: Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism. Clin. Res. 36, 384, 1988. (abstr.)

    Google Scholar 

  25. Brown J.P., Delmas P.D., Malaval L., et al: Serum bone GLA-protein: A specific marker for bone formation in postmenopausal osteoporosis. Lancet i, 1091–1092, 1984.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Juntendo, University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Madoka Arisaka, Osamu Arisaka, Atsuto Hosaka, Akifumi Tokita, Naoto Shimura & Keijiro Yabuta

  2. The Second Division, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo

    Yoshindo Kawaguchi

Authors
  1. Madoka Arisaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Osamu Arisaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Atsuto Hosaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Akifumi Tokita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Naoto Shimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Keijiro Yabuta
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yoshindo Kawaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Arisaka, M., Arisaka, O., Hosaka, A. et al. Osteoporosis in a boy with hypogonadotropic hypogonadism. JBMM 7, 18–22 (1989). https://doi.org/10.1007/BF02911529

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02911529

Keywords

Search

Navigation