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Dynamic life cycle of parathyroid hormone

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Summary

Attempts were made to review the biological and physiological significance of the processing and degradation of PTH in the parathyroid gland, liver bone and kidney. Degradation of PTH may be connected with its action, in addition to its physiological role of controlled disposal of the active hormone regulating the half-life of the hormone in circulation. Recent demonstration of receptor-mediated limited cleovage of PTH at specific sites may represent one step forward in the elucidation of the significance of degradation in PTH action beyond the receptor. Actions of the PTH fragments thus generated may provide the key for the understanding of the significance of PTH degradation. Studies on PTH degradation may open way to the understanding of the physiological significance of the degradation of all the peptide hormones.

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  1. Department of Medicine, Kobe University School of Medicine, Kobe, Japan

    Takuo Fujita M.D.

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Fujita, T. Dynamic life cycle of parathyroid hormone. JBMM 7, 1–7 (1989). https://doi.org/10.1007/BF02911526

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