Summary
In spite of the refinement of hepatic tests, no new light could be shed upon the pathogenesis of hepatic coma. In addition, it is stressed again that the results of hepatic tests in preterminal hepatic insufficiency with coma are not significantly different from those obtained in cases of hepatic insufficiency which recover. Blood non-protein nitrogen, urea nitrogen, and the blood amino-acids were simultaneously and significantly elevated. The suggestions of Dr. Hans Popper in the performance of this study are greatly appreciated. Thanks are due to Miss Lois Davis for her help in the statistical analysis of the data.
Similar content being viewed by others
References
Mann, F. C.: The role of the liver as the commissariat of the body. Am., J. Digest. Dis. and Nutrition. 4:355, 1937.
Popper, H. and Schaffner, F.: Hepatic tests. Adv. Int. Med., Vol. 4. The Year Book Publishers, Inc., Chicago, 1950.
Sherlock, S.: Biochemical investigations in liver disease: some correlations with hepatic histology. J. Path, and Bact. 58:523, 1946.
Franklin, M., Popper, H., Steigmann, F. and Kozoll, D.D.: Relation between structural and functional alterations of liver. J. Lab. & Clin. Med. 33:435, 1948.
Popper, H., Steigmann, F., Meyer, K. A., Kozoll, D. D. and Franklin, M.: Correlation of liver function and liver structure. Clinical Applications. Am. J. Med. 6:278, 1949.
Popper, H., Steigmann, F., and Szanto, P. B.: Quantitative correlation of morphologic liver changes and clinical tests. Am. J. Clin. Path. 19:710, 1949.
Norcross, J. W., Feldman, J. D., Bradley, R. F. and White, R. M.: Liver function: An attempt to correlate structural change with functional abnormality. Ann. Int. Med. 35:110, 1951.
Murphy, T. L., Chalmers, T. C., Eckhardt, R. D. and Davidson, C. S.: Hepatic coma. New Eng. J. Med. 239:605, 1948.
Greene, H. C.: Liver and biliary tract. Progress in internal medicine. Arch. Int. Med. 67:867, 1941.
Lichtman, S. S.: Diseases of the liver, gall bladder and bile ducts. 2nd Ed. Lea and Febiger, Philadelphia, 1949.
Hanger, F. M., Jr.: The flocculation of cephalin-cholesterol emulsions by pathologic sera. Tr. A. Am. Physicians 53:148, 1939.
Maclagan, M. F.: Thymol turbidity test. A new indicator of liver dysfunction. Nature 154:670, 1944.
Kunkel, H. G.: Estimation of serum gamma globulin by a turbidimetric technique. Proc. Soc. Exper. Biol. and Med. 66:217, 1947.
Huerga de la, J., Yesinick, C., and Popper, H.: Estimation of total serum lipids by a turbidimetric method. In preparation.
Chaney, A. L.: Personal communication.
Gomori, G.: Determination of phenol in biologic material. J. Lab. and Clin. Med. 34:275,1949.
Bodansky, A.: Phosphatase studies. II. Determining serum phosphatase. Factors influencing the accuracy of the determination. J. Biol. Chem. 101: 93, 1933.
Watson, C. J. and Ducci, H.: The quantitative determination of serum bilirubin with special reference to the prompt reacting and chloroform soluble types. J. Lab. and Clin. Med. 30: 293, 1945.
Malloy, H. T., and Evelyn, K. A.: The determination of bilirubin with the photoelectric colorimeter. J. Biol. Chem. 119: 481, 1937.
Howe, P. E.: The determination of protein in blood, a micro-method. J. Biol. Chem. 49: 909, 1921.
Wolfson, W. Q., Cohn, C., Calvary, E. and Ichiba, F.: Studies in serum proteins: V. Rapid procedure for the estimation of total protein, true albumin, total globulin, alpha globulin, beta globulin, and gamma globulin in 1.0 ml of serum. Am. J. Clin. Path. 18: 723, 1948.
Huergade la, J., and Popper, H.: Estimation of serum gamma globulin concentration by turbidimetry. J. Lab. and Clin. Med. 35:459, 1950.
Hoffman, W. S.: Photelometric clinical chemistry. William Marrow and Co., New Tork, 1941.
Hoffman. W. S.: A photometric adaptation of the Rolin method for determination of plasma amino-acid nitrogen. Am. J. Clin. Path. 15: 57, 1945.
Bockus. H. L.: Gastroenterology. Vol. III. W. B. Saunders Co., Philadelphia, 1946.
Cantarow. A. and Trumper, M.: Clinical Biochemistry. 3rd Ed. W. B. Saunders Co., Philadelphia, 1945.
Miller, L. L., Bly, CLG., Watson, M. L. and Bale, W. F.: The dominant role of the liver plasma protein synthesis: A direct study of the isolated perfused rat liver with the aid of lysine-e-C14. 94: 431, 1951.
Meyer, K. A., Popper, H. and Steigmann, F.: Significance of rise of nonnrotein nitrogen in medical and surgical jaundice. J. A. M. A. 117:847, 1950.
Popper, H., Waldstein, S. and Szanto, P.: Correlation of clinical features of cirrhosis of liver with findings on biopsy. Am. J. Clin. Path. 20: 724, 1950.
Goldbloom, R. S. and Steigmann, F.: Aureomycin therapy in hepatic insufficiency. Gastroenterology. 18: 93, 1951.
Lepper., M. H., Wolfe, C. K., Zimmerman, H. J., Caldwell, E. R., Jr., Spies, H. W. and Dowling, H. F.: Effect of large doses of aureomyein in human liver. Arch. Int. Med. 88: 271, 1951.
Walshe, J. M.: Observations on the symptomatology and pathogenesis of hepatic coma. Quart. J. Med. 20: 421, 1951.
Author information
Authors and Affiliations
Additional information
Supported by a grant from the Doctor Jerome D. Solomon Memorial Research Foundation.
Rights and permissions
About this article
Cite this article
Switzer, J.L., Steigmann, F., de la Huerga, J. et al. Hepatic tests in preterminal hepatic insufficiency. Amer. Jour. Dig. Dis. 19, 241–244 (1952). https://doi.org/10.1007/BF02910768
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02910768