Summary
The experience gained in a pilot programme for multiple screening for amino acid disorders is reported. Over 222,000 newborn infants were screened by ion-exchange chromatography using dried blood spots. The acceptability, reliability and validity of the method are reported, and an outline is given of the field evaluation of the method over 4 years, together with a short cost analysis. Incidences of the screened diseases and their differences from other reports are also discussed.
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Antonozzi, I., Santagata, G. & Tofani, R. Multiple neonatal screening for aminoacidopathies by ion-exchange chromatography. La Ricerca Clin. Lab. 12, 507–515 (1982). https://doi.org/10.1007/BF02909403
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DOI: https://doi.org/10.1007/BF02909403