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Cryoglobulins and immune complexes in essential mixed cryoglobulinemia

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Ricerca in clinica e in laboratorio

Summary

The authors review the role, clinico-serological correlations and the putative pathogenetic relevance of a number of immunological parameters in essential mixed cryoglobulinemia. On the whole, in spite of the fact that levels of cryoglobulins, immune complexes, complement as well as reticuloendothelial splenic function are frequently abnormal in this condition, they are generally poorly correlated with clinical features. Therefore, it is postulated that this apparent discrepancy may either be due to the contemporary presence in the same serum of many types of immune complexes with different toxicity, or to the influence of rheumatoid factor on the nature of circulating immune complexes.

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Authors and Affiliations

  1. Cattedre di Immunologia Clinica e di Patologia Medica III, Servizio di Reumatologia, Università degli Studi di Pisa, Italia

    Stefano Bombardieri, Clodoveo Ferri, Paola Migliorini, Aldo Pontrandolfo, Antonio Puccetti, Claudio Vitali & Giampiero Pasero

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  1. Stefano Bombardieri
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  2. Clodoveo Ferri
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  3. Paola Migliorini
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  4. Aldo Pontrandolfo
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  5. Antonio Puccetti
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  6. Claudio Vitali
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  7. Giampiero Pasero
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Bombardieri, S., Ferri, C., Migliorini, P. et al. Cryoglobulins and immune complexes in essential mixed cryoglobulinemia. La Ricerca Clin. Lab. 16, 281–288 (1986). https://doi.org/10.1007/BF02909351

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