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T lymphocyte subpopulations defined by monoclonal antibodies in essential mixed cryoglobulinemia and in secondary cryoglobulinemias

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Ricerca in clinica e in laboratorio

Summary

T lymphocyte subpopulations defined by monoclonal antibodies were determined in patients with essential mixed cryoglobulinemia (EMC) and secondary cryoglobulinemias (SC). A decrease of circulating lymphocytes and a reduction in the absolute number of T3+, T4+ and T8+ (p<0.01) as well as in the percentage of T4+ lymphocytes (p<0.05) were found in EMC. A significant decrease of T8+ cells, both in percentage (p<0.01) and absolute number (p<0.001), was evidenced in SC, while T3+ and T4+ cell counts were not significantly different from those of healthy controls.

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References

  1. Invernizzi F., Pioltelli P., Cattaneo R., Gavazzeni V., Borzini P., Monti G., Zanussi C.: A long-term follow-up study in essential cryoglobulinemia — Acta haematol. (Basel)61, 93, 1979.

    Article  CAS  Google Scholar 

  2. Levo Y.: Nature of cryoglobulinaemia — Lanceti, 285, 1980.

    Article  Google Scholar 

  3. Meroni P. L., Barcellini W., De Bartolo G., Invernizzi F., Zanussi C.: Abnormalities ofin vitro immunoglobulin synthesis by peripheral blood lymphocytes from patients with essential mixed cryoglobulinemia — Clin. Immunol. Immunopathol.33, 245, 1984.

    Article  PubMed  CAS  Google Scholar 

  4. Meroni P. L., Barcellini W., Messina C., De Bartolo G., Capsoni F., Invernizzi F.: Defective suppressor cell activity in essential mixed cryoglobulinemia — J. clin. Lab. Immunol.8, 177, 1982.

    PubMed  CAS  Google Scholar 

  5. Meroni P. L., Ciboddo G. F., Colombo G., Bonara P., Invernizzi F.: T cell defect in essential mixed cryoglobulinaemia — Int. Arch. Allergy59, 308, 1979.

    PubMed  CAS  Google Scholar 

  6. Zanussi C.: Le crioglobulinemie miste essenziali: un modello di ricerca immunoclinica. In: Atti IV Congr. Soc. Ital. Immunol. e Immunopatol., Firenze, 1980; p. 107.

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Galli, M., Monti, G., Irato, L. et al. T lymphocyte subpopulations defined by monoclonal antibodies in essential mixed cryoglobulinemia and in secondary cryoglobulinemias. La Ricerca Clin. Lab. 16, 275–279 (1986). https://doi.org/10.1007/BF02909350

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  • DOI: https://doi.org/10.1007/BF02909350

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