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Human melanoma-associated antigens identified with monoclonal antibodies

Structural profile and potential usefulness in immunodiagnosis and immunotherapy

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Ricerca in clinica e in laboratorio

Summary

Using monoclonal antibodies three types of membrane-bound tumour-associated antigens have been identified on human melanoma cells. The tissue distribution, the immunological profile and the structural properties of these melanoma-associated antigens (MAA) are described. The applications of the monoclonal antibodies to one of the MAA in the area of immunodiagnosis and immunotherapy are discussed.

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Author information

Authors and Affiliations

  1. Departments of Pathology and Surgery, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, 10032, New York, N.Y., USA

    Barry S. Wilson, Kohzoh Imai, Toshihiro Nakanishi & Soldano Ferrone

  2. Laboratorio di Immunologia, Istituto Regina Elena, Roma

    Patrizio Giacomini, Pier Giorgio Natali & Giovanna Ruberto

Authors
  1. Barry S. Wilson
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  2. Patrizio Giacomini
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  3. Kohzoh Imai
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  4. Pier Giorgio Natali
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  5. Toshihiro Nakanishi
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  6. Giovanna Ruberto
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  7. Soldano Ferrone
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Additional information

This work was supported by the National Institutes of Health, grants AI 19189, CA 32609, CA 32619, CA 32634, CA 32635, a special fellowship from the Leukemia Association of America (B. S. Wilson) and a fellowship fromAssociazione Italiana per la Ricerca sul Cancro (AIRC) (P. Giacomini). P. G. Natali was supported byConsiglio Nazionale delle Ricerche (CNR), Roma, Italy, ‘Progetto Finalizzato Controllo della Crescita Neoplastica’, grant no. 80.01599.96.

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Wilson, B.S., Giacomini, P., Imai, K. et al. Human melanoma-associated antigens identified with monoclonal antibodies. La Ricerca Clin. Lab. 12, 517–538 (1982). https://doi.org/10.1007/BF02909339

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