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References
Beisiegel U., Kita T., Anderson G. W., Schneider W. J., Brown M. S., Goldstein J. L.: Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver — J. biol. Chem.256, 4071, 1981.
Brown M. S., Kovanen P. T., Goldstein J. L.: Regulation of plasma cholesterol by lipoprotein receptors — Science212, 628, 1981.
Fredrickson D. S., Goldstein J. L., Brown M. S.: The familial hyperlipoproteinemias. In:Stanbury J. B., Wyngaarden J. B., Fredrickson D. S. (Eds): Metabolic basis of inherited disease. McGraw-Hill Book Co., New York, 1978; chapt. 30, p. 604.
Fredrickson D. S., Levy R. I., Lees R. S.: Fat transport in lipoproteins: an integrated approach to mechanisms and disorders — New Engl. J. Med.276, 32, 94, 148, 215, 273, 1967.
Goldstein J. L., Brown M. S.: Binding and degradation of low-density lipoproteins by cultured human fibroblasts — J. biol. Chem.249, 5153, 1974.
Gregg R. E., Zech L. A., Schaefer E. J., Brewer H. B.: Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E — Science211, 584, 1981.
Havel R. J., Chao Y. S., Windler E. E., Kotite L., Guo L. S.: Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia — Proc. nat. Acad. Sci. (Wash.)77, 4349, 1980.
Hazzard W. R., Warnick G. R., Utermann G., Albers J. J.: Genetic transmission of isoapolipoprotein E phenotypes in a large kindred: relationship to dysbetalipoproteinemia and hyperlipidemia — Metabolism30, 79, 1981.
Hui D. Y., Innerarity T. L., Mahley R. W.: Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo E and apo B, E receptors — J. biol. Chem.256, 5646, 1981.
Pagnan A., Havel R. J., Kane P., Kotite L.: Characterization of human very low density lipoproteins containing two electrophoretic populations: double pre-beta lipoproteinemia and primary dysbetalipoproteinemia — J. Lipid Res.18, 613, 1977.
Schneider W. J., Kovanen P. T., Brown M. S., Goldstein J. L., Utermann G., Weber W., Havel R. J., Kotite L., Kane J. P., Innerarity T. L., Mahley R. W.: Familial dysbetalipoproteinemia: abnormal binding of mutant apoprotein E to LDL receptors of human fibroblasts and membranes from liver and adrenals of rats, rabbits and cows — J. clin. Invest.68, 1075, 1981.
Shelbourne F. A., Quarfordt S. H.: A new apoprotein of human plasma very low density lipoproteins — J. biol. Chem.249, 1428, 1974.
Sherrill B. C., Innerarity T. L., Mahley R. W.: Rapid hepatic clearance of the canine lipoproteins containing only the E apoproteins by a high affinity receptor. Identity with the chylomicron remnant transport process — J. biol. Chem.255, 804, 1980.
Soltys P. A., Portman O. W.: Low density lipoprotein receptors and catabolism in primary cultures of rabbit hepatocytes — Biochim. biophys. Acta (Amst.)574, 505, 1979.
Utermann G.: Isolation and partial characterization of an arginine-rich apoprotein from human plasma very low density lipoproteins: apolipoprotein E — Hoppe-Seylers Z. physiol. Chem.256, 1113, 1975.
Utermann G.: Polymorphism of apolipoprotein E. In:Gotto A. M., Jr.,Smith L. C., Allen B. (Eds): Atherosclerosis. Springer-Verlag, New York, 1980; vol. V, p. 689.
Utermann G., Canzler H., Hees M., Jaeschke M., Mühlfellner G., Schoenborn W., Vogelberg K. H.: Studies on the metabolic defect in broad β disease (hyperlipoproteinemia type III) — Clin. Genet.12, 139, 1977.
Utermann G., Hees M., Steinmetz A.: Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinemia in man — Nature (Lond.)269, 604, 1977.
Utermann G., Jaeschke M., Menzel J.: Familial hyperlipoproteinemia type III. Deficiency of a specific apolipoprotein (Apo E-III) in the very low density lipoproteins —Febs Letters56, 352, 1975.
Utermann G., Langenbeck U., Beisiegel U., Weber W.: Genetics of the apolipoprotein E system in man — Amer. J. hum. Genet.32, 339, 1980.
Utermann G., Pruin N., Steinmetz A.: Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man — Clin. Genet.15, 63, 1979.
Utermann G., Steinmetz A., Weber W.: Genetic control of human apolipoprotein E polymorphism: comparison of one- and two-dimensional techniques of isoprotein analysis — Amer. J. hum. Genet. (Submitted for publication).
Utermann G., Vogelberg K. H., Steinmetz A., Schoenborn W., Pruin N., Jaeschke M., Hees M., Canzler H.: Polymorphism of apolipoprotein E. II. Genetics of hyperlipoproteinemia type III — Clin. Genet.15, 37, 1979.
Utermann G., Weber W., Beisiegel U.: Different mobility in SDS-polyacrylamide gel electrophoresis of apolipoprotein E from phenotypes Apo E-N and Apo E-D —Febs Letters101, 21, 1979.
Warnick G. R., Mayfield C., Albers J. J., Hazzard W. R.: Gel isoelectric focusing method for specific diagnosis of familial hyperlipoproteinemia type III — Clin. Chem.25, 279, 1979.
Weidman W. S., Suarez B., Falko J. M., Witzum J. L., Kolar J., Raben M., Schonfeld G.: Type III hyperlipoproteinemia: development of a VLDL Apo E gel isoelectric focusing technique and application in family studies — J. Lab. clin. Med.93, 549, 1979.
Weisgraber K. H., Mahley R. W.: Apoprotein (E-A II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction — J. biol. Chem.253, 6281, 1978.
Weisgraber K. H., Rall S. C. Jr.,Mahley R. W.: Human E apoprotein heterogeneity: cysteine-arginine interchanges in the amino acid sequence of the apo E isoforms — J. biol. Chem.256, 9077, 1981.
Zannis V. J., Breslow J. L.: Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and post-translational modification — Biochemistry20, 1033, 1981.
Zannis V. J., Just P. W., Breslow J. L.: Human apolipoprotein E isoprotein subclasses are genetically determined — Amer. J. hum. Genet.33, 11, 1981.
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Utermann, G. Apolipoprotein E. La Ricerca Clin. Lab. 12, 23–33 (1982). https://doi.org/10.1007/BF02909306
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DOI: https://doi.org/10.1007/BF02909306