Summary
We observed CFU-Mix of 4 normal adults and 11 cases of leukemia. The culture system used by us in this study represented a suitable model for studying differentiation of hemopoietic stem cells in vitro. The pathogenesis of myeloid-lymphoid bipotent leukemia were malignant changes in pluripotent hemopoietic progenitor cells. The leukemic clones showed proliferation, but did not mature in culture. It is suggested that differentiation of leukemic stem cell did not pass through CFU-Mix stage.
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References
1987;14:459–62.
Ash RC, et al. Studies on human plu-ripotential hemopoietic stem cells (CFU-GEMM) in vitro. Blood 1981:58:309–16.
Messner NA, et al. Identification of T lympocytes in human mixed hemopoietic colonies. Blood 1981;58:402–5.
McCulloch EA. Stem cells in normal and leukemic hemopoiesis. Blood 1983;62: 1–13.
Griffin JD, et al. Clonogenic in acute myeloblastic leukemia. Blood 1986;68: 1185–95.
Bettelheim P, et al. Expression of a myeloid marker on TdT-positive acute lymphocytic leukemic cells: evidence by double-fluorescence staining. Blood 1982; 60:1392–6.
1989;4:209–10.
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Yan, C., Bian-ming, W., Chong-yu, L. et al. Scanning electron microscopic observation of CFU-Mix of normal adults and leukemic patients including two cases of myeloid-lymphoid bipotent leukemia. Journal of Tongji Medical University 10, 23–26 (1990). https://doi.org/10.1007/BF02909117
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DOI: https://doi.org/10.1007/BF02909117