Summary
Extracelluar recording method was used to examine the effect of thyrotropin-releasing hormone (TRH) on 71 unit discharges of pain-excited neurons (PEN) in mesencephalic reticular formation (MRF) in 58 rats. Intracerebroventricular (icv) injection of TRH (10 Hg/10 μ) produced significant decrease of pain discharge rate of PEN. TRH potentiated the inhibitory effect of el elctroacupuncture (EA) on nociceptive discharges when application of EA at bilateral “Zusanli” was coupled with icv injection of TRH. Both of these inhibiting effects of TRH were completely offset or strikingly decreased by icv preinject ion of the cholinergic M-receptor blocker atropine. The results mentioned above and the mechanism of the inhibitory effect of TRH on pain discharges were discussed in this paper.
Similar content being viewed by others
References
Griffiths EC, Bennett GW, eds. Thyrotropin-releasing hormone. Raven Press 1983. pp. 96–101; 271–90.
Foschi G, et al. Antinociceptive properties of thyrotropin-releasing hormone in mice: comparison with morphine. Br J Pharmacol 1983; 79:85–92.
Kawamura S, et al. The antinociceptive effect of histisyl-proline diketopiperazine and thyrotropin-releasing hormone in the mouse. Eur J Pharmacol 1985; 112:287–94.
Yarbrough GG. Minireview. Thyrotropin-releasing hormone and CNS cholinergic neurons. Life Sci 1983; 33:111–8.
1977:402.
Mendez M, et al. Regional distribution of in vitro release of thyrotropin-releasing hormon in rat train. Peptides 1987; 8:291–8.
Funatsz K, et al. Various types of thyrotropin-releasing hormone receptors in discrete brain regions and the pituitary of the rat. J Neurochem 1985; 45: 390–7
Kizer T, et al. Releasing factors in the circumventricular organs of the rat brain. Endocrinology 1976; 98:311–7.
Butler PD, Eodnar RJ. Neuromodulatory effect of TRH upon swine and cholinergic analgesia. Peptides 1987;8:299–307.
Yarbrough GG. Studies on the neuropharmacology of thyrotropin releasing hormone (TRH) and a new TRH analog Eur J Pharmacol 1978;48:19–27.
Pirola CJ, et al. Thyrotropin releasing hormone increases the number of muscarinic receptors in the lateral septal area of the rat brain. Brain Res 1983; 273:387–91.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zuo-yan, L., Hong-mei, X. & Chang-jin, L. Effect of Intracerebroventricular injection of thyrotropin-releasing hormone on the nociceptive discharges in mesencephalic reticular formation in the rat. Journal of Tongji Medical University 9, 251–256 (1989). https://doi.org/10.1007/BF02909093
Issue Date:
DOI: https://doi.org/10.1007/BF02909093