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Problems in hemophilia therapy

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Ricerca in clinica e in laboratorio

Summary

At present, the future of patients with hemophilia A may be regarded with more optimism due to advances in diagnosis and management which have occurred in recent years. However, a number of problems are still unresolved and others are now emerging against this optimistic background. The development of an inhibitor specifically destroying factor VIII coagulant activity renders the management at best difficult. It has been recognized recently that multitransfused hemophiliacs have a high incidence of abnormal liver function tests, and there is preliminary evidence that these are the expression of chronic active liver disease. This review is focused on these pitfalls of hemophilia care and emphasizes the recent developments in these fields and their impact on the pattern of life of hemophiliacs.

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Authors and Affiliations

  1. Centro per l’Emofilia e la Trombosi Angelo Bianchi Bonomi Clinica Medica III, Università degli Studi di Milano Ospedale Policlinico, Via Pace 15, 20122, Milano, Italia

    Pier Mannuccio Mannucci

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Mannucci, P.M. Problems in hemophilia therapy. La Ricerca Clin. Lab. 11, 301–311 (1981). https://doi.org/10.1007/BF02909029

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