Abstract
Metaplasia is a known predisposing factor to malignancy. As squamous metaplasia is a regular feature of atrophic rhinitis, its relationship with cancer is examined in this cross-sectional study. Random punch biopsies of nasal mucosa obtained from 14 patients (6 male and 8 female) suffering from primary atrophic rhinins were studied. Squamous metaplasia was noted in 64%. Epithelial dysplasia and in-situ malignant transformation were noted in one patient each. This preliminary report suggests that the association of atrophic rhimitis and pre-cancerous lesions appear to be more than coincidental and it deserves further studies.
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References
Shehata MA. Atrophic rhinitis. Am J Otolaryngol 1996; 17: 81–6.
Chen HS. Desqnamation and squamotransformation of rhinomucosa as a prodromal sign of atrophic rhinitis ORL J Otorhinolaryngol Relat Spec 1984; 46: 327–8.
Slack JM, MetaplasiaIn: Mc Gee JO, Issacson PG wright NA. Dick HM, Slack MPE (editors). Oxford textbook of pathology, volume 1. Oxford University Press. 1992, p. 565–8.
Sinha SN, Samuel KC, Juneja TM, Mittal DP. Astudy of the histology and exfoliative cytology of atrophic rhinitis. J Laryngol Otol 1975; 89: 1027–41.
Friedmann I, Osborn DA. Carcinoma of the surface epithelium.In: Pathology of granulomas and neoplasms of the nose and paranasal sinuses. London: Churchill Livingstone: 1982; p118–32.
Rodrignez-Afrados F, Estvill J. Carcinogenic action of the implant of acrylic tabs in ozena. Rhinology 1997; 25: 213–5.
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Raveenthiran, V. Pre-cancerous changes in the nasal mucosa of atrophic rhinitis: A preliminary report. Indian J Otolaryngol Head Neck Surg 57, 28–29 (2005). https://doi.org/10.1007/BF02907622
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DOI: https://doi.org/10.1007/BF02907622