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A note on the biological activity of root extracts fromPleiocarpa mutica Benth. (Apocynaceae)

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Abstract

Several organic solvent and aqueous extractives were prepared from dried roots ofPleiocarpa mutica Benth. obtained from the Belgium Congo. All aqueous fractions produced a drop in blood pressure when administered to laboratory rats. A moist ethyl acetate extract produced most significant hypotensive activity. Preliminary tests indicate the presence of alkaloids in the active extracts of this species, and that the activity blocks the effect of epinephrine but is not altered by atropine. The active acetate fraction also destroyed adult and larvae stages of the nematode,Panagrellus redivivus (L.) Goody when added to test cultures.

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Literature Cited

  1. Raymond-Hamet, M. Pharmacologie Végétale—Sur un nouvel hypotenseur a. action durable, fourni par une Apocynacée du Congo Beige: lePleiocarpa tubicinaStapf., Compt. rend.244: 2991. 1957.

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  2. Kiang, A. K. and Douglas, B. A. Phytochemical Survey Part I Alkaloids. Malayan Pharm. Jour.6: 138. 1957.

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  3. Rauffauf, R. F. and Flagler, M. B. “Alkaloids of the Apocynaceae,”; Econ. Bot.14: 37. 1960.

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Authors and Affiliations

  1. Laboratories of Pharmacognosy and Pharmacology, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island

    H. W. Youngken

Authors
  1. D. P. N. Tsao
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  2. J. A. Rosecrans
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  3. J. J. Defeo
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  4. H. W. Youngken
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Additional information

Supported in part by funds from grant B-1360 of the National Institutes of Health, Bethesda, Maryland.

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Tsao, D.P.N., Rosecrans, J.A., Defeo, J.J. et al. A note on the biological activity of root extracts fromPleiocarpa mutica Benth. (Apocynaceae). Econ Bot 15, 99–103 (1961). https://doi.org/10.1007/BF02906766

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  • DOI: https://doi.org/10.1007/BF02906766

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