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Sex hormone binding globulin in breast cancer

  • Margaret Bowen
  • A. Milford Ward
  • Jane Humphreys
  • R. Charles Coombes
Original Contributions
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Summary

Using a binding assay for sex hormone binding globulin, a Japanese group showed that they could select breast cancer patients more likely to be responsive to endocrine therapy, i.e. oestrogen receptor positive patients, by an increase in oestrogen binding capacity of the protein. We directly measured the levels of this protein using a specific antiserum to it, and the levels were not different from normal in any group of breast cancer patients whether or not oestrogen receptors were present. Both methods of measurement can detect a slight increase after a weak oestrogenic stimulus, indicating that they are as sensitive as each other.

Key words

Breast cancer Cytosol oestrogen receptors Oestrogen Sex hormone binding globulin SP2 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Margaret Bowen
    • 1
  • A. Milford Ward
    • 2
  • Jane Humphreys
    • 3
  • R. Charles Coombes
    • 3
  1. 1.The Unit for Cancer ResearchUniversity of LeedsGreat Britain
  2. 2.Department of ImmunologyRoyal Hallamshire HospitalSheffield
  3. 3.Ludwig Institute for Cancer ResearchRoyal Marsden HospitalSutton

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