Sex hormone binding globulin in breast cancer

  • Margaret Bowen
  • A. Milford Ward
  • Jane Humphreys
  • R. Charles Coombes
Original Contributions


Using a binding assay for sex hormone binding globulin, a Japanese group showed that they could select breast cancer patients more likely to be responsive to endocrine therapy, i.e. oestrogen receptor positive patients, by an increase in oestrogen binding capacity of the protein. We directly measured the levels of this protein using a specific antiserum to it, and the levels were not different from normal in any group of breast cancer patients whether or not oestrogen receptors were present. Both methods of measurement can detect a slight increase after a weak oestrogenic stimulus, indicating that they are as sensitive as each other.

Key words

Breast cancer Cytosol oestrogen receptors Oestrogen Sex hormone binding globulin SP2 


  1. 1.
    Anderson D. C.: Letter to the Editor - Nature (Lond.)240, 38, 1972.CrossRefGoogle Scholar
  2. 2.
    Bohn H.: Isolierung, Charakterisierung und quantitative immunologische Bestimmung des steroid-bindenden β-Globulins -Blut29, 17, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    Bohn H.: Immunochemical determination of human pregnancy proteins - Arch. Gynäk.217, 219, 1974.CrossRefGoogle Scholar
  4. 4.
    Mancini G., Carbonara A. O., Heremans J. F.: Immunochemical quantitation of antigens by single radial immunodiffusion - Immunochemistry2, 235, 1965.PubMedCrossRefGoogle Scholar
  5. 5.
    McGuire W. L., Carbone P. P., Sears M. E., Escher G. C.: Estrogen receptors in human breast cancer: an overview - In:McGuire W. L., Carbone P. P., Vollner E. P. (Eds): Estrogen receptors in human breast cancer. Raven Press, New York, 1975; p. 1.Google Scholar
  6. 6.
    Murayama Y., Utsunomiya J., Asano K.: Sex hormone binding globulin predicts response of breast cancer to hormone therapy - Lancetii, 1356, 1977.CrossRefGoogle Scholar
  7. 7.
    Murayama Y., Utsunomiya J., Takahashi I., Kitamura M., Tominaga T.: Sex hormone binding globulin as a reliable indicator of hormone dependence in human breast cancer - Ann. Surg.190, 133, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Sakai F., Cheix F., Clavel M., Colon J., Mayer M., Pommatau E., Saez S.: Increase in steroid binding globulins induced by tamoxifen in patients with carcinoma of the breast - J. Endocr.76, 219, 1978.PubMedCrossRefGoogle Scholar
  9. 9.
    Scatchard G.: The attraction of proteins for small molecules and ions - Ann. N.Y. Acad. Sci.51, 660, 1949.CrossRefGoogle Scholar
  10. 10.
    Svendsen P. J., Rose C.: Separation of proteins using ampholine carrier ampholytes as buffer and spacer ions in an isotachophoresis system - Science Tools17, 13, 1970.Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Margaret Bowen
    • 1
  • A. Milford Ward
    • 2
  • Jane Humphreys
    • 3
  • R. Charles Coombes
    • 3
  1. 1.The Unit for Cancer ResearchUniversity of LeedsGreat Britain
  2. 2.Department of ImmunologyRoyal Hallamshire HospitalSheffield
  3. 3.Ludwig Institute for Cancer ResearchRoyal Marsden HospitalSutton

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