Summary
Serum angiotensin-converting enzyme activity was measured in 72 patients with sarcoidosis and in 50 normal controls by a radiochemical assay. SACE levels were examined with respect to the ‘activity’ of the disease, based on clinical, radiographic and physiological assessment. SACE activity in 34 patients with clinical sarcoidosis (147±44.3 nmol/min/ml) was significantly high (p<0.001) when compared to that of 38 patients who had recovered from sarcoidosis (113.9±26.4 nmol/min/ml) and 50 normal subjects (97.8±21 nmol/min/ml). SACE levels were significantly different (p<0.01) between 15 subjects with ‘active’ disease (173.9±51.9 nmol/min/ml) and those with ‘inactive’ disease (126.1±26.3 nmol/min/ml). It is concluded that there is a strict correlation between SACE levels and ‘activity’ of sarcoidosis if multiple criteria (clinical, radiographic and physiological) are employed.
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Tassi, G., Nava, A.M., Bettoncelli, G. et al. Determination of serum angiotensin-converting enzyme in sarcoidosis. La Ricerca Clin. Lab. 14, 621–627 (1984). https://doi.org/10.1007/BF02906301
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DOI: https://doi.org/10.1007/BF02906301