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Coagulation factor VII

Biochemistry, role in blood coagulation, methods of assay, congenital deficiencies and relationship with thrombosis

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Ricerca in clinica e in laboratorio

Summary

Factor VII is a trace plasma protein which is very reactive and can be activated through several enzymatic pathways. It has been postulated that factor VII has all the features of an initiator of the clotting mechanism. The severe congenital deficiency of factor VII is characterized by a clinical picture which is not distinguishable from that observed in hemophilias. The presence of factor α-VIIa in the circulation in clinical conditions associated with thrombosis leads to the assumption that this factor, when activated, may play an important role in thrombogenesis. The variants of factor VII congenital deficiency and the methods currently employed to assay factor VII in various conditions are reviewed.

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Authors and Affiliations

  1. Cattedra di Ematologia, Università degli Studi di Roma, Via Chieti 7, 00161, Roma, Italia

    Guglielmo Mariani & Franco Mandelli

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  1. Guglielmo Mariani
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  2. Franco Mandelli
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Additional information

This work was supported in part by a grant fromConsiglio Nazionale delle Ricerche (CNR), Roma, Italy,Progetto Finalizzato ‘Ingegneria Genetica’, Sottoprogetto ‘Basi Molecolari delle Malattie Ereditarie’.

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Mariani, G., Mandelli, F. Coagulation factor VII. La Ricerca Clin. Lab. 13, 287–298 (1983). https://doi.org/10.1007/BF02905872

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