Summary
The proteinuria was measured in two-kidney hypertensive rats, in rats made hypertensive by aortic stenosis, in one-kidney hypertensive rats and in a group of control sham-operated animals. It was significantly increased in those of the first and second groups in direct correlation with the PRA which was elevated, while it was only slightly raised in those of the third group with a normal PRA. Following removal of the clip the proteinuria decreased in the two-kidney hypertensive rats, whilst it increased in the other two groups. It is suggested that in the latter cases the increase in protein excretion after removal of the clip could be due to an increase in the blood flow and filtration rate of the revascularized kidneys, whilst in the former this effect could be masked by the constant decrease in proteinuria from the intact kidney due to the fall in the PRA.
Similar content being viewed by others
References
Addis T.: Proteinuria and cylindruria—Proc. Calif. Acad. Med.43, 52, 1931.
Bilde T.: The effect of temporary clamping of the renal vessels on the vascular resistance in rabbit kidneys—Scand. J. Urol. Nephrol.10, 52, 1976.
Boyd G. W., Fitz A. E., Adamson A. R., Peart W. S.: Radioimmunoassay determination of plasma renin activity—Lanceti, 213, 1969.
Carpentier C. C. J., Davis J. O., Ayers C. R.: Relation of renin, angiotensin II and experimental hypertension to aldosterone secretion—J. clin. Invest.40, 2026, 1961.
Deodhar S. D., Cuppage F. E., Gableman E.: Studies on the mechanism of experimental proteinuria induced by renin—J. exp. Med.120, 677, 1964.
Fudjii J., Yasaki Y.: Renin, electrolytes and water intake in two types of experimental renal hypertension—Amer. J. Physiol.222, 979, 1972.
Gross F.: The renin-angiotensin system and hypertension—Ann. Intern. Med.75, 777, 1971.
Meyer Ph.: The role of the renin-angiotensin system in the pathogenesis of high blood pressure— In: Progress in cardiology. Lea and Febiger, Philadelphia, 1974; p. 189.
Nanson E. M., Noble J. G.: Effect on kidneys of cross-clamping abdominal aorta distal to renal arteries—Surgery46, 388, 1959.
Noble R. P.: Electrophoretic separation of plasma lipoproteins in agarose-gel—J. Lipid Res.9, 693, 1968.
Pessina A. C., Hulme B., Peart W. S.: Renin-induced proteinuria and the effects of adrenalectomy. II. Morphology in relation to function—Proc. roy. Soc. B180, 61, 1972.
Pessina A. C., Peart W. S.: Renin-induced proteinuria and the effects of adrenalectomy. I. Haemodynamic changes in relation to function—Proc. roy. Soc. B180, 43, 1972.
Pirrelli A., Pieri R.: La proteinuria da angiotensina: laclearance siero-proteica—Boll. Soc. ital. Biol. sper.49, 130, 1973.
Sellers A. L., Smith S., Marmorston J., Goodman H. C.: Studies on the mechanism of experimental proteinuria—J. exp. Med.96, 643, 1952.
Swales J. D., Tange J. D.: The influence of acute sodium depletion on experimental hypertension in the rat—J. Lab. clin. Med.78, 369, 1971.
Author information
Authors and Affiliations
Additional information
This research was supported by theConsiglio Nazionale delle Ricerche (CNR), Roma, Italy, contract no. 77.01672.04.
Rights and permissions
About this article
Cite this article
Pessina, A.C., Pauletto, P., Pagnan, A. et al. The mechanism of proteinuria in three different models of renovascular hypertension in the rat. La Ricerca Clin. Lab. 8, 158–166 (1978). https://doi.org/10.1007/BF02904988
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02904988