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Role of complement and antibodies in the control and facilitation of HIV disease

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Pathology & Oncology Research

Abstract

In humans the HIV infection results in a chronic disease with a permanent fight between factors controlling HIV and the escape of the virus. Fromthese control mechanisms the present review summarizes the role betwen complement and autoantibodies; the competition of complement and anti-HIV antibodies for binding sites, the role of mannan-binding lectin in the susceptibility to and in the survival after HIV infection, the contribution of complement-dependent enhancing type antibodies to the clinical progression of HIV disease as well as the changing pattern of some autoantibodies (mimicking MHC class II molecules, anti-heat shock protein 60 antibodies and anti-C1q antibodies) which were found to correlate to immunological and clinical parameters.

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Author information

Authors and Affiliations

  1. 3rd Department of Medicine, Research Laboratory, Semmelweis Medical University of Medicine, Eötvös út 12, 1121, Budapest, Hungary

    Zoltán ProhÁszka & George FÜst

  2. Research Group for Membrane Biology and Immunopathology, National Academy of Sciences, Budapest

    Zoltán ProhÁszka & George FÜst

  3. Institute of Microbiology, University Medical School, Debrecen

    Ferenc D TÓth

  4. Department of Immunology, St. László Hospital, Budapest, Hungary

    Dénes BÁnhegyi

Authors
  1. Zoltán ProhÁszka
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  2. Ferenc D TÓth
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  3. Dénes BÁnhegyi
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  4. George FÜst
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Correspondence to Zoltán ProhÁszka.

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ProhÁszka, Z., TÓth, F.D., BÁnhegyi, D. et al. Role of complement and antibodies in the control and facilitation of HIV disease. Pathol. Oncol. Res. 3, 296–302 (1997). https://doi.org/10.1007/BF02904290

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  • DOI: https://doi.org/10.1007/BF02904290

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