Abstract
Cholestasis is the failure of bile to reach duodenum due to three different mechanisms: a. alteration of bile secretion by hepatocytes into the canaliculus with or without liver cell damage; b. obstruction of the intrahepatic bile ducts caused by diseases of ductules or small/medium bile ducts; c. obstruction of extrahepatic bile ducts. This short review focuses on drugs which may induce cholestasis by any of these mechanisms.
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References
Review by an international group: Histopathology of the intrahepatic tree. Liver 3: 161–175, 1983.
Erlinger S: What is cholestasis in 1985? J Hepatol 1:687–693, 1985.
Sherlock S: Drugs and the liver.In: Diseases of the liver and biliary system, 6th edn. Oxford: Blackwell Scientific Publications: pp 295–322, 1991.
Pessayre D, Larrey D: Drug-induced liver injury. In: Oxford Textbook Of Clinical Hepatology. Oxford University Press: pp 875–902, 1991.
Stricker BHCh, Blok APR, Desmet VJ: Pathology of drug- induced hepatic injury. In: Drug-induced hepatic injury, 2nd edn. Elsevier: pp 51–70, 1992.
Stricker BHCh, Biour M, Wilson JHP: Individual agents: drugs. In: Drug-induced hepatic injury, 2nd edn. Elsevier, 1992.
Zimmerman HJ, Ishak KG: Hepatic injury due to drugs and tox- ins. In: Pathology of the liver, 3rd edn.Churchill Livingstone: pp 563–633, 1995.
Degott C, Feldmann G, Larrey D, et al: Drug-induced prolonged cholestasis in adults: A histological semiquantitative study demonstrating progressive ductopenia. Hepatology, 15:244–251, 1992.
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This lecture was given at the XXI International Congress of International Academy of Pathology, Budapest, 1996.
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Degott, C. Drug-induced liver injury. Pathol. Oncol. Res. 3, 260–263 (1997). https://doi.org/10.1007/BF02904284
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DOI: https://doi.org/10.1007/BF02904284