Abstract
Lanthanum chloride (1 mM) inhibits the activity of acetylcholinesterasein vitro in the human erythrocyte membrane. Lineweaver-Burk analysis indicates that lanthanum chloride induced inhibition of acetylcholinesterase activity is competitive in nature. The Arrhenius plot shows that the transition temperature of erythrocyte membrane-bound acetylcholinesterase is significantly reduced in the presence of lanthanum chloride. These results suggest that lanthanum chloride increases the fluidity of the erythrocyte membrane and this may be a cause of inhibition of membrane-bound acetylcholinesterase activity.
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Abbreviations
- AChE:
-
Acetylcholinesterase
- ACD:
-
acid citrate dextrose
- LaCl3:
-
lanthanum chloride
- TT:
-
transition temperature
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Mukhopadhyay, S., Mukhopadhyay, S., Bhattacharyya, D.K. et al. Interaction of lanthanum chloride with human erythrocyte membrane in relation to acetylcholinesterase activity. J Biosci 13, 123–128 (1988). https://doi.org/10.1007/BF02903093
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DOI: https://doi.org/10.1007/BF02903093