Abstract
The effects of two luteinizing hormone releasing hormone analogues (a superagonist and an antagonist) on the conversion of testosterone to dihydrotestosterone in homogenates prepared from adult rat ventral prostates were studied. At higher doses, the superagonist showed a significant dose-dependent inhibition of the conversion of testosterone to dihydrotestosterone. In comparison, the antagonist showed only a marginally inhibitory trend. The implications of these observed effects vis-a-vis the use of the analogues in the endocrine management of prostatic cancer have been discussed.
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Abbreviations
- LHRH:
-
Luteinizing hormone releasing hormone
- DHT:
-
dihydrotestosterone
References
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Maitra, A., Joseph, R., Sheth, A.R. et al. Effect of luteinizing hormone releasing hormone analogues on testosterone metabolismin vitro — A study with mature rat ventral prostates. J Biosci 13, 105–108 (1988). https://doi.org/10.1007/BF02903090
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DOI: https://doi.org/10.1007/BF02903090