Summary
A study of T and B cell surface markers was carried out on peripheral blood lymphocytes from diabetic patients, employing immunofluorescent staining for membrane Ig, and the E rosette test. According to the immunofluorescent studies the % of sIg bearing lymphocytes decreases with age; this trend is more evident in healthy individuals. Lymphocytes from diabetic patients possess a higher amount of membrane IgG than age-matched controls. It was only in the younger diabetic patients that a definite decrease was observed in the % of IgM bearing lymphocytes. The evaluation of E rosette-forming lymphocytes revealed a similar age-associated reduction both in diabetics and in controls. Some common features of the pattern of T and B cell markers on lymphocytes from younger diabetic patients and older controls suggest that the former undergo, at least from the immunological standpoint, a more precocious ageing process. It is possible that some metabolic disorders in lymphocyte activity may play a role in this, resulting in a deficiency in the control of immunological mechanisms.
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Perussia, B., Tossi, B. & Rugarli, C. B and T cell surface markers on peripheral lymphocytes from diabetic patients. La Ricerca in Clin. Lab. 6, 326–331 (1976). https://doi.org/10.1007/BF02899979
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DOI: https://doi.org/10.1007/BF02899979