Pathology & Oncology Research

, Volume 3, Issue 3, pp 224–228 | Cite as

Three cases of HIV-1 seroreversion

  • Veronika TarjÁn
  • Eszter Üjhelyi
  • János SzabÓ
  • Robert Kellner
  • Géza Krall
  • Ágnes Gyuris
  • Ilona MihÁly
  • George FÜst
Special report


Three patients were enrolled, two as hemophiliacs, and one with acute EBV infection. Serial serum samples of each patient were tested with at least 3 different HIV antibody EIA tests, an immunofluo-rescent test and two western blots (WB). In the third case, PCR and reverse transcriptase enzyme activity measurement were also done. One of the regularly checked serum samples of hemophiliac patients was reactive with different HIV screening and confirmatory assays. Their next blood samples, two weeks and one month later, respectively, were negative with the same tests. In Case 3. two and a half years after the first examination, the EIA tests results changed to negative, but the WB was still indeterminate. In the case of the two hemophiliac patients, the patients may have been exposed to HIV containing blood products (before 1985), but were not infected. Regular treatment with factor VIII concentrate, in which HIV antigens may be present, can boost the immune response and results in transient seropositivity. In the case of the EBV infected patient, the transient HIV seropositivity may be the consequence of EBV induced proliferation of anti-HIV-antibody producing B cell clones. During our ten year HIV confirmatory practice we tested more than 40000 samples, from which transient seropositivity were observed only in the three cases summarized in this paper.

Key words

HIV transient seropositivity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Lallemant M, Lapointe N, et al: Perinatal HIV Transmission. In AIDS in the World Edited by Mann J., Tarantola D.J.M., Netter T.W Harvard University Press 629–645, 1992.Google Scholar
  2. 2.
    Bryson YJ: HIV clearence in infants - a continuing saga. AIDS 9:1373–1375, 1995.PubMedCrossRefGoogle Scholar
  3. 3.
    Roques PA, Gras G, Parnet-Mathieu F;et al: Clearance of HIV infection in 12 perinatally infected children: clinical, virological and immunological data. AIDS 9:F19-F26, 1995.PubMedGoogle Scholar
  4. 4.
    Simpson BJ, Andiman WA: Difficulties in assigning HIV-1 infection and seroreversion status in a cohort of HIV-exposed children using serologic criteria established by the Centers for Disease Control and Prevention. Pediatrics 93:840–842, 1994.PubMedGoogle Scholar
  5. 5.
    Chantry CJ, Cooper ER, Pelton SI, et al.: Seroreversion in human immunodeficiency virus-exposed but uninfected infants. Pediatr Infect Dis J 14:382–387, 1995.PubMedCrossRefGoogle Scholar
  6. 6.
    Farzadegan H, Polis MA, Wolinsky SM, et al.: Loss of human immunodeficiency virus Type 1 (HIV-1) antibodies with evidence of viral infection in asymptomatic homosexual men. Ann Intern Med 108:785–790, 1988.PubMedGoogle Scholar
  7. 7.
    Tenenbaum SA, Leissinger CA, Garry RF: Absence of serocon- version of HIV-1 antibody in seroreactive Individuals. JAMA 270:2178–2179, 1993.PubMedCrossRefGoogle Scholar
  8. 8.
    Burger H, Weiser B, Robinson WS, et al: Transient antibody to lymphadenopathy-associated virus/Human T-Lymphotropic Virus Type III and T-lymphocyte abnormalities in the wife of a man who developed the acquired immunodeficiency syndrome. Ann Intern Med 103:545–547, 1985.PubMedGoogle Scholar
  9. 9.
    Roy MJ, Damato JJ, Burke DS: Absence of true seroreversion of HIV-1 antibody in seroreactive individuals. JAMA 270:2178–2179, 1993.CrossRefGoogle Scholar
  10. 10.
    Morb Mortal Weekly Report 38, 1989.Google Scholar
  11. 11.
    Gartner S, Popovic M: Technics in HIV Research. Ed. by Aldovini A, Walker BD, Stockton Press, 1990.Google Scholar
  12. 12.
    Somogyi PA, Gyuris Á, Földes I: A solid phase reverse tran- scriptase-micro assay for the detection of Human Immunodefficiency Virus and other Retroviruses in cell culture supernatants. J Virol Methods 27:269–276, 1990.PubMedCrossRefGoogle Scholar
  13. 13.
    Holmberg S.D., Horsburgh C.R., Byers R.H. Errors in reporting seropositivity for infection with human immunodeficiency virus (HIV). Ann Intern Med 107:679–680, 1988.Google Scholar
  14. 14.
    Újhelyi E., Králl G., Füst G., et al. Prevalence of HIV-antibod-ies in patients with hemophilia In Hungary. Haematologia. 21:83–89, 1988.PubMedGoogle Scholar

Copyright information

© Arányi Lajos Foundation 1997

Authors and Affiliations

  • Veronika TarjÁn
    • 1
  • Eszter Üjhelyi
    • 1
  • János SzabÓ
  • Robert Kellner
    • 2
  • Géza Krall
    • 3
  • Ágnes Gyuris
    • 4
  • Ilona MihÁly
    • 5
  • George FÜst
    • 6
  1. 1.National Transfusion CenterBudapestHungary
  2. 2.Blood Transfusion CenterBaja
  3. 3.National Institute of Hematology and ImmunologyBudapest
  4. 4.National Institute of Public HealthBudapest
  5. 5.St. Láaszló HospitalBudapest
  6. 6.3rd Department of MedicineSemmelweis University of MedicineBudapestHungary

Personalised recommendations