Abstract
Natural and modified preparations of lipopolysaccharides and lipopolysaccharide-protein complexes isolated from the S- and R-form ofShigella dysenteriae serovar 1 were found to markedly inhibit the initial growth of mouse solid tumors derived from N’emeth-Kellner lymphoma, Gardner 6C3HED lymphoma, an ill-defined syngeneic lymphoma of DBA mice (Skalsky lymphoma) and LP-2 plasmacytoma. The biopreparations were given intraperitoneally, most frequently at a dose range from 50 to 200 μg per mouse; significant inhibitory effects on tumor growth were evidenced even in mice bearing tumors weighing 113 to 507 mg.
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Šourek, J., Oravec, C. & Männel, D.S. Bacterial endotoxins as potential antitumor agents. Folia Microbiol 37, 450–454 (1992). https://doi.org/10.1007/BF02899904
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DOI: https://doi.org/10.1007/BF02899904