Summary
The relevance of bronchus-associated lymphoid tissue (BALT) in man is still under discussion. Animal experiments indicate that the development of BALT is dependent on microbial stimulation. Therefore, the incidence of BALT was investigated retrospectively in specimens removed during surgical procedures on patients with chronic pulmonary inflammation. All these patients had severe chronic bronchitis and bronchiectasis, but BALT was found in only 8%. In patients with BALT and a malignant tumor, occlusion of a bronchus with poststenotic pneumonia was always present and BALT was observed exclusively in areas peripheral to the occlusion. In man other compartments of the lung must be responsible for the immune function of BALT found in animals.
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References
Bienenstock J (1984) Bronchus-associated lymphoid tissue. In: Bienenstock J (ed) Immunology of the lung and upper respiratory tract. McGraw-Hill, New York, pp 96–118
Bienenstock J, Johnston N (1976) A morphologic study of rabbit bronchial lymphoid aggregates and lymphoepithelium. Lab Invest 35:343–348
Bienenstock J, Johnston N, Perey DYE (1973) Bronchial lymphoid tissue. I. Morphologic characteristics. Lab Invest 28:686–692
Daniele RP (1990) Immunoglobulin secretion in the airways. Ann Rev Physiol 52:177–195
Delventhal S, Hensel A, Petzoldt K, Pabst R (1992) Effects of microbial stimulation on the number, size and activity of bronchus-associated lymphoid tissue (BALT) structures in the pig. Int J Exp Pathol 73:351–357
Hruban RH, Beschorner WE, Baumgartner WA, Achuff SC, Traill TA, Digennaro KA, Reitz BA, Hutchins GM (1988) Depletion of bronchus-associated lymphoid tissue associated with lung allograft rejection. Am J Pathol 132:6–11
Kradin RL, Mark EJ (1983) Benign lymphoid disorders of the lung, with a theory regarding their development. Hum Pathol 14:857–867
McDermott MR, Befus AD, Bienenstock J (1982) The structural basis for immunity in the respiratory tract. Int Rev Exp Pathol 23:47–112
Meuwissen HJ, Hussain M (1982) Bronchus-associated lymphoid tissue in the human lung: Correlation of hyperplasia with chronic pulmonary disease. Clin Immunol Immunopathol 23:548–561
Pabst R (1992) Is BALT a major component of the human lung immune system? Immunol Today 13:119–122
Pabst R, Gehrke I (1990) Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Am J Respir Cell Mol Biol 3:131–135
Peters U, Papadopoulos T, Muller-Hermelink HK (1990) MHC Class II antigens on lung epithelia of human fetuses and neonates. Lab Invest 63:38–43
Rankin JA, Reynolds HY (1985) Pulmonary host defenses: humoral immune components. Adv Host Def Mechan 4:115–140
Sminia T, van der Brugge-Gamelkoorn GJ (1989) Structure and function of bronchus-associated lymphoid tissue (BALT). Crit Rev Immunol 9:119–150
Stockley RA (1990) Cellular and humoral mechanisms. In: Brewis RAL, Gibson GJ, Geddes DM (eds) Respiratory medicine. Bailliere Tindall, London, pp 189–203
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Delventhal, S., Brandis, A., Ostertag, H. et al. Low incidence of bronchus-associated lymphoid tissue (BALT) in chronically inflamed human lungs. Virchows Archiv B Cell Pathol 62, 271–274 (1992). https://doi.org/10.1007/BF02899692
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DOI: https://doi.org/10.1007/BF02899692