Summary
Samples of 130 metastatic melanomas from 92 patients were analyzed by DNA flow cytometry. DNA aneuploidy was observed in 67% of the patients. DNA indices were evenly distributed from 0.6 to 2.6 Tumors originating from primary lesions in the lower extremities were more frequently DNA aneuploid than those of other sites. S-phase fraction (SPF) was evaluable from 73 tumors. DNA aneuploid tumors had a significantly higher SPF than diploid tumors, and females had a higher SPF than males. Furthermore, distant metastases had a higher SPF than metastases in regional lymph nodes and in transit metastases, probably indicating a higher growth potential in metastases spreading to distant sites.
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Muhonen, T., Pyrhönen, S., Laasonen, A. et al. DNA ploidy pattern and S-phase characteristics of metastatic melanoma. Virchows Archiv B Cell Pathol 60, 253–257 (1991). https://doi.org/10.1007/BF02899554
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DOI: https://doi.org/10.1007/BF02899554