Summary
There appear to be four primary areas of interest in the application of cytogenetic techniques to the study of malignant lymphomas: (1) the role of cytogenetics in the diagnosis of lymphoma in problem cases, (2) as an aid to the classification of malignant lymphomas, (3) whether specific chromosomal patterns will have prognostic significance for response to therapy or survival, and (4) the role of cytogenetics in staging of malignant lymphomas. A case of reactive lymphoid hyperplasia is reported in which cytogenetic studies demonstrated an aneuploid clone suggesting that cytogenetic abnormalities of lymphoma may precede the diagnostic histopathologic picture. The occurrence of 14q+ marker chromosomes in plasmacytic myeloma, plasma cell leukemia, malignant lymphomas, Burkitt’s lymphoma, and ataxia-telangiectasia suggest that a common etiologic or pathogenetic mechanism may be present in some of these disorders. A preliminary pilot study of spleens removed at staging laparotomy for Hodgkin’s disease suggests that cytogenetic studies may be able to detect Hodgkin’s disease that is not apparent histologically. Further studies are required to provide answers to these areas of interest in cytogenetics in malignant lymphoma.
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Bochkov, N.P., Lopukhin, Y.M., Kuleshov, N.P., Kovalchuk, L.V.: Cytogenetic study of patients with ataxia-telangiectasia. Humangenetik24, 115–128 (1974)
Cohen, M.M., Shaham, M., Dagan, J., Shmueli, E., Kohn, G.: Cytogenetic investigations in families with ataxia-telangiectasia. Cytogenet. Cell Genet.15, 338–356 (1975)
Fukahara, S.: Significance of 14q translocations in non-Hodgkin lymphomas. Virchows Arch. B Cell Path.29, 99–106 (1978)
Harnden, D.G.: Ataxia-telangiectasia syndrome: Cytogenetic and cancer aspects. In: Chromosomes and Cancer, pp. 619–636. Ed. J. German. New York: John Wiley & Sons, 1974
Hayashi, K., Schmid, W.: Tandem duplication q14 by end to end chromosome fushion in ataxia-telangiectasia (AT). Clinical and cytogenetic findings in 5 patients. Humangenetik30, 135–141 (1975)
Hook, E.B., Hatcher, N.H., Calka, O.J.: Apparent “in situ” clone of cytogenetically marked ataxia-telangiectasia lymphocytes. Humangenetik30, 251–258 (1975)
Jarvis, J.E., Ball, G., Rickinson, A.B., Epstein, M.A.: Cytogenetic studies on human lymphoblastoid cell lines from Burkitt’s lymphomas and other sources. Int. J. Cancer14, 716–721 (1974)
Levitt, R., Pierre, R.V., Siekert, R.G., White, W.L.: Atypical lymphoid leukemia in ataxiatelangiectasia. Blood (in press)
Manolov, G., Manolova, Y.: Marker band in one chromosome 14 from Burkitt lymphomas. Nature237, 33–34 (1972)
McCaw, B.K., Epstein, A.L., Kaplan, H.S., Hecht, F.: Chromosome 14 translocation in African and North American Burkitt’s lymphoma. Int. J. Cancer19, 482–486 (1977)
McCaw, B.K., Hecht, F., Harnden, D.G., Teplitz, R.L.: Somatic rearrangement of chromosome 14 in human lymphocytes. Proc. Natl. Acad. Sci. USA72, 2071–2075 (1975)
Oxford, J.M., Harnden, D.G., Parrington, J.M., Delhanty, J.D.A.: Specific chromosome aberrations in ataxia telangiectasia. J. Med. Genet.12, 251–262 (1975)
Patil, S.R., Merrick, S., Lubs, H.A.: Identification of each human chromosome with a modified Giemsa stain. Science173, 821–822 (1971)
Rary, J.M., Bender, M.A., Kelly, T.E.: A 14/14 marker chromosome lymphocyte clone in ataxia-telangiectasia. J. Hered.66, 33 (1975)
Tjio, J.H., Whang, J.: Chromosome preparations of bone marrow cells without prior in vitro culture or in vivo colchicine administration. Stain Technol.37, 17–20 (1962)
Wurster-Hill, D.: Chromosome studies in myelomatosis. Virchows Arch. B Cell Path.29, 93–97 (1978)
Zech, I., Haglund, Y., Nilsson, K., Klein, G.: Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphoma. Int. J. Cancer17, 47–56 (1976)
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Pierre, R.V. Cytogenetics in malignant lymphoma. Virchows Arch. B Cell Path. 29, 107–112 (1978). https://doi.org/10.1007/BF02899343
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DOI: https://doi.org/10.1007/BF02899343