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Current pathogenetic and molecular concepts in viral liver carcinogenesis

  • Published:
Virchows Archiv B

Summary

Hepatocellular carcinoma (HCC) is one of the most frequent malignancies in humans and in most cases a consequence of chronic infection of the liver by hepatotropic viruses (Hepatitis B Virus (HBV) and possibly Hepatitis C Virus (HCV)). Formation of HCC results from a stepwise process involving different preneoplastic lesions that reflect multiple genetic events, like protooncogene activation, tumor suppressor gene inactivation, and growth factor overor reexpression. Recent investigations have gained new insights into how these factors are activated and may interact. In addition, improved knowledge of the molecular biology of HBV has led to better understanding of its pleiotropic effects on induction and progression in hepatocarcinogenesis

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Authors and Affiliations

  1. Institute of Pathology, University Hospital, Langenbeckstrasse 1, W-6500, Mainz, Federal Republic of Germany

    Peter Schirmacher & Hans P. Dienes

  2. Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, 10461, Bronx, NY, USA

    Charles E. Rogler

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  1. Peter Schirmacher
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  2. Charles E. Rogler
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  3. Hans P. Dienes
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Schirmacher, P., Rogler, C.E. & Dienes, H.P. Current pathogenetic and molecular concepts in viral liver carcinogenesis. Virchows Archiv B Cell Pathol 63, 71–89 (1993). https://doi.org/10.1007/BF02899246

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  • DOI: https://doi.org/10.1007/BF02899246

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