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Lymphocyte mediated cell lysis

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Virchows Archiv B

Summary

Lymphocyte-mediated cell lysis represents an important immunologic effector mechanism involved in defense against viral infections, allograft rejection, and tumor surveillance. Moreover, regulatory T cell interactions within the immune system are based, at least in part, on molecular events related to this function. The multiplicity of effector cell populations that can mediate cytotoxicity, the cell/cell interaction determinants which they require for execution of their activities, and molecular events underlying the lytic process itself, as elucidated recently, are the subjects of the present review article.

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  1. Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Institut für Radiologie und Pathophysiologie, Im Neuenheimer Feld 280, D-6900, Heidelberg, Federal Republic of Germany

    Stefan C. Meuer & Hans P. Dienes

  2. Pathologisch-Anatomisches Institut, Johannes Gutenberg-Universität, Langenbeckstraße 1, D-6500, Mainz, Federal Republic of Germany

    Hans P. Dienes

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  1. Stefan C. Meuer
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  2. Hans P. Dienes
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Meuer, S.C., Dienes, H.P. Lymphocyte mediated cell lysis. Virchows Archiv B Cell Pathol 57, 1–9 (1989). https://doi.org/10.1007/BF02899059

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