Skip to main content
Log in

Multivalent vaccines: Prospects and challenges

  • Published:
Folia Microbiologica Aims and scope Submit manuscript

Abstract

The advantages and disadvantages of combination vaccines are set out with a clear indication that, although there are many (described and discussed) influences on in the immunogenicity of a vaccine it would still be of considerable value to be able to deliver such materials with the minimum number of needle-stick injections. Such a situation may become facilitated in the future as vaccines based on plasmid DNA become available; a prospect which is examined in outline in the final section.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bloom B.R.: A perspective on issues relating to future vaccines; inCombined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 388–395 (1995).

    Article  CAS  Google Scholar 

  • Dimarchi R., Brooke G., Gale C.: Protection of cattle against foot-and-mouth disease by a synthetic peptide.Science 232, 639 (1986).

    Article  PubMed  CAS  Google Scholar 

  • Ellis R.: Challenges and development of combination vaccines, pp. 127–132 inNovel Strategies in the Design and Production of Vaccines (A. Cohen, A. Shafferman, Eds). Plenum Press, London 1996.

    Google Scholar 

  • Halperin S.A., Eastwood B.J., Langley J.M.: Immune responses to pertussis vaccines concurrently administered with viral vaccines; inCombined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 89–96 (1995).

    Article  CAS  Google Scholar 

  • Halsey N.A.: Practical considerations regarding the impact on immunization schedules of the introduction of new combined vaccines; inCombined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 250–254 (1995).

    Article  CAS  Google Scholar 

  • Human Tissue:Ethical and Legal Issues, p. 153. Nuffield Council on Bioethics, London 1995.

  • Liu M.A., Hilleman M.R., Kurth R. (Eds):DNA Vaccines: A New Era in Vaccinology. New York Acad. Sci., Vol. 772 (1995).

  • McLintock D.K.: Combination vaccines: regulatory issues; inCombined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 27–34 (1995).

    Article  Google Scholar 

  • Paradiso P.R.: Combination vaccines for diphtheria, tetanus, pertussis andHœmophilus influenzœ type b; inCombined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 108–113 (1995).

    Article  CAS  Google Scholar 

  • Parkman P.D.:Combined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 1–9 (1995).

    Article  CAS  Google Scholar 

  • Šebo P.: paper presented at aFEMS Internat. Symp. Novel Methods and Standardization in Microbiology, Košice (Slovakia) 1996.

  • Smith H.: Report in vaccine,in press (1996).

  • Spier R.E.: Report of a meeting on vaccines; new technologies and applications.Vaccine 13, 1038–1039 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Spier R.E.: Meeting report for vaccine,in press (1996).

  • Sutter R.W., Pallansch M.A., Sawyer L.A., Cochi S.L., Hadler S.C.: Defining surrogate serological tests with respect of predicting protective vaccine efficacy: polio vaccination; inCombined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 289–299 (1995).

    Article  CAS  Google Scholar 

  • Wassilak S.G., Glasser J.W., Chen R.T., Hadler S.C. and the vaccine safety data link investigators: Utility of large-linked databases in vaccine safety, particularly in distinguishing independent and synergistic effects; inCombined Vaccines and Simultaneous Administration: Current Issues and Perspectives (J.C. Williams, K.L. Goldenthal, D.L. Burns, B.P. Lewis Jr., Eds).Ann.New York Acad.Sci. 754, 377–382 (1995).

    Article  CAS  Google Scholar 

  • Wolf J.A., Malone R.W., Williams P., Chong W., Acsadi G., Jani A., Felgner P.L.: Direct gene transfer into mouse musclein vivo.Science 247, 1465–1468 (1990).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Given at aFEMS International Symposium on Novel Methods and Standardization in Microbiology, at Košice (Slovakia), July 1–4, 1996.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spier, R.E. Multivalent vaccines: Prospects and challenges. Folia Microbiol 42, 105–112 (1997). https://doi.org/10.1007/BF02898716

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02898716

Keywords

Navigation