Summary
One hundred and forty-eight children with tuberculosis of the various organs (lungs, pleura, lymphnodes, intestine, peritoneum) were given thiacetazone and isoniazid daily for the first month and then twice a week to study the intolerance to these drugs as manifested by signs and symptoms for a period ranging from 1 month to 24 months.
Twenty-five children (16.9%) had some adverse reactions like nausea, vomiting, anorexia, diarrhoea, pruritis, rashes and urticaria, during the first month of therapy except one child who developed a bluish discoloration of the nails after about 9 months of therapy. None of these manifestations was severe enough to warrant withdrawal of the drugs.
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From the Department of Child Health, R.N.T. Medical College, Udaipur.
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Bhandari, B., Jain, A.M., Kulshrestha, S.K. et al. Intermittent isoniazid and thiacetazone in childhood tuberculosis with reference to clinical intolerance. Indian J Pediatr 39, 20–23 (1972). https://doi.org/10.1007/BF02898558
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DOI: https://doi.org/10.1007/BF02898558