Skip to main content
SpringerLink
Log in

Daily lifestyles and anti-mutagenicity of saliva

  • Original Article
  • Published:
Environmental Health and Preventive Medicine Aims and scope

Abstract

Objectives

The purpose of this study was to investigate the relation between lifestyle and the antimutagenicity of saliva.

Methods

Subjects were 52 healthy female university students. The collection of the saliva samples and the lifestyle measurements were carried out for them. The anti-mutagenicity of the saliva was measured using the umu test.

Results

With regard to the lifestyle items, only “nutrient balance” tended to contribute positively to the inhibiting capacity of the saliva on the mutagenicity of AF-2. In addition, there was a significant inverse correlation between the score of 7 other items and the inhibiting capacity of the saliva (r=−0.32; p<0.05). We also found a significant relation between their tea and/or coffee consumption and the inhibiting capacity of the saliva.

Conclusions

These findings suggest that the inhibiting capacity of saliva worked to decrease mutagen levels that were enhanced by poor lifestyle. In addition, “nutrient balance” may contribute to the inhibiting capacity of the saliva independent of 7 other items. With regard to the tea and/or coffee consumption. further studies should be carried out.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yamaguchi M, Takai N. Saliva as a mirror of the body (in Japanese). Tokyo:Kongyou-chousakai. 1999.

    Google Scholar 

  2. Nishioka H, Nishi K, Kyokane K. Human saliva inactivates mutagenicity of carcinogens. Mutat. Res. 1981; 85: 323–333.

    PubMed  CAS  Google Scholar 

  3. Nishioka H, Nunoshiba T. Role of enzymes in antimutagenesis of human saliva and serum. Basic. Life Sci. 1986; 39: 143–151.

    PubMed  CAS  Google Scholar 

  4. Okada M, Nakamura S, Miura K, Morimoto K. The antimutagenic effects of human saliva investigated by umu-test-1 Effects of filtration and storage at low temperatures (in Japanese). Jpn. J. Hyg. 1989; 44: 1009–1013.

    CAS  Google Scholar 

  5. Stich HF, Chan PKL, Rosin MP. Inhibitory effects of phenolics, teas and saliva on the formation of mutagenic nitrosation products of salted fish. Int. J. Cancer 1982; 30: 719–724.

    Article  PubMed  CAS  Google Scholar 

  6. Wang CK, Peng CH. The mutagenicities of alkaloids andN-nitrosoguvacoline from betel quid. Mutat. Res. 1996; 360: 165–171.

    PubMed  CAS  Google Scholar 

  7. Bhide SV, Kulkarni J, Nair UJ, Spiegelhalder B, Preussmann R. Mutagenicity and carcinogenicity ofMasheri, a pyrolysed tobacco product, and its content of tobacco-specific nitrosamines. IARC Sci. Publ. 1987; 84: 460–462.

    PubMed  Google Scholar 

  8. Kada T, Kato M, Aikawa K, Kiriyama S. Adsorption of pyrolysate by vegetable fibers. Mutat. Res. 1984; 141: 149–152.

    Article  PubMed  CAS  Google Scholar 

  9. Morimoto K. “Stress-kiki no yobo-igaku” (in Japanese). Tokyo: NHK books 1997.

    Google Scholar 

  10. Kusaka Y, Kondou H, Morimoto K. Healthy lifestyles are associated with higher natural killer cell activity. Prev. Med. 1992; 21: 602–615.

    Article  PubMed  CAS  Google Scholar 

  11. Hagihara A, Morimoto K. Personal health practices and attitudes toward nonsmokers' legal rights in Japan. Soc. Sci. Med. 1991; 33: 717–721.

    Article  PubMed  CAS  Google Scholar 

  12. Ferguson DB, Botchway CA. Circadian variations in the flow rate and composition of whole saliva stimulated by mastication. Archs. Oral Biol. 1980; 24: 877–881.

    Article  Google Scholar 

  13. Uenobe F, Nakamura S, Miyazawa M. Antimutagenic effect of resveratrol against Trp-P-1. Mutat. Res. 1997; 373; 197–200.

    PubMed  CAS  Google Scholar 

  14. Nakamura S, Kosaka H. Modification activity of human serum on SOS-inducing activity of chemical mutagens (in Japanese). Proceedings of Osaka prefectural institute of public health 1993; 31: 23–28.

    CAS  Google Scholar 

  15. Miller JH. Experimentals in molecular genetics. In: Cold Spring Harbor Laboratory. New York: Cold Spring Harbor, 1972: 352–355.

    Google Scholar 

  16. Oda Y, Nakamura S, Oki I, Kato T, Shinagawa H. Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens. Mutat. Res. 1985; 147: 219–229.

    PubMed  CAS  Google Scholar 

  17. Nakamura S. Development of screening test for mutagens (in Japanese). “Kagaku to kougyou” 1988; 62: 142–148.

    CAS  Google Scholar 

  18. Nakamura S, Oda Y, Shimada T, Oki I, Sugimoto K. SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. Mutat. Res. 1987; 192: 239–246.

    Article  PubMed  CAS  Google Scholar 

  19. Yamamoto N, Sugiura W, Kosaka H, Nakamura S. The SOS-inhibition activity of human urine investigated by umu-test: Diurnal and daily changes of SOS-inhibition activity of urine (in Japanese). Jpn. J. Hyg. 1994; 49: 791–796.

    CAS  Google Scholar 

  20. Ames BN, McCann J, Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 1975; 31: 347–364

    PubMed  CAS  Google Scholar 

  21. Mure K, Takeshita T, Takeuchi T, Morimoto K. Urinary mutagens and lifestyle factors. Prev. Med. 1996; 25: 569–574.

    Article  PubMed  CAS  Google Scholar 

  22. Mure K, Hayatsu H, Takeuchi T, Takeshita T, Morimoto K. Heavy cigarette smokers show higher mutagenicity in urine. Mutat. Res. 1997; 373: 107–111.

    PubMed  CAS  Google Scholar 

  23. Toda M, Morimoto K, Nakamura S, Umeda T, Nakaji S, Sugawara K. The unique correlation between anti-mutagenicity of human saliva and change in body weight. Environ. Health Prev. Med. 2001; 6: 82–87.

    Article  Google Scholar 

  24. Navazesh M, Christensen CM. A comparison of whole mouth resting and stimulated salivary measurement procedures. J. Dent. Res. 1982; 61: 1158–1162.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Social and Environmental Mediciae, Osaka University Gradaate School of Medicine, 2-2 Yamada-Oka, 565-0871, Suita, Osaka, Japan

    Masahiro Toda & Kanehisa Morimoto

  2. Health Research Foundation, Kyoto

    Sei-ichi Nakamura

  3. Department of Comnunity Health, School of Health Sciences, Osaka University, Osaka

    Kazuo Hayakawa

Authors
  1. Masahiro Toda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kanehisa Morimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sei-ichi Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazuo Hayakawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kanehisa Morimoto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Toda, M., Morimoto, K., Nakamura, Si. et al. Daily lifestyles and anti-mutagenicity of saliva. Environ Health Prev Med 7, 11–14 (2002). https://doi.org/10.1007/BF02898060

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02898060

Key words

Search

Navigation