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Detection of anti-topoisomerase I autoantibody in patients with silicosis

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Environmental Health and Preventive Medicine Aims and scope

Abstract

Objectives

The aim of this study was to detect anti-topoisomerase I (anti-topo I) autoantibodies, which are known to be limited in systemic sclerosis patients, in silicosis patients with no clinical symptoms of autoimmune disease.

Methods

Serum anti-topo I autoantibodies were detected using ELISA. Differences in clinical parameters between patients with and without anti-topo I autoantibodies were analyzed.

Results

Seven of 69 patients had anti-topo I autoantibodies. These 7 patients showed elevated PaCO2 values (P=0.0212), and inverse correlations between serum soluble Fas levels and PaCO2 values were found.

Conclusion

Anti-topo I autoantibodies were detected in 10.1% of silicosis patients without any clinical symptoms of autoimmune disease. The findings here suggest that the genesis of anti-topo I autoantibodies might be related to pulmonary involvement or lung fibrosis associated with progression of silicosis.

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Authors and Affiliations

  1. Department of Hygiene, Kawasaki Medical School, 577 Matsushima, 701-0192, Kurashiki, Okayama, Japan

    Akiko Tomokuni, Takemi Otsuki, Haruko Sakaguchi, Yumika Isozaki, Fuminori Hyodoh & Ayako Ueki

  2. Department of Internal Medicine, Kusaka Hospital, Okayama

    Masayasu Kusaka

Authors
  1. Akiko Tomokuni
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  2. Takemi Otsuki
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  3. Haruko Sakaguchi
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  4. Yumika Isozaki
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  5. Fuminori Hyodoh
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  6. Masayasu Kusaka
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  7. Ayako Ueki
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Corresponding author

Correspondence to Akiko Tomokuni.

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Tomokuni, A., Otsuki, T., Sakaguchi, H. et al. Detection of anti-topoisomerase I autoantibody in patients with silicosis. Environ Health Prev Med 7, 7–10 (2002). https://doi.org/10.1007/BF02898059

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  • DOI: https://doi.org/10.1007/BF02898059

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