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Stress- and aging-associated modulation of macrophage functions

Environmental Health and Preventive Medicine volume 6, Article number: 218 (2002) Cite this article

Abstract

Effects of environmental (cold) stress and aging on cells in monocyte/macrophage lineage were investigated. We demonstrated that immune suppressive states seen in acute cold-stressed mice (8–10 weeks of age) is attributable to FcγRIIbright suppressor macrophages. Serum corticosterone levels were markedly increased in acute cold-stressed mice. In addition, expression of glucocorticoids (GC) receptor mRNA was observed in FcγRIIbright cells from these mice. The increase of FcγRIIbright cells in peritoneal exudate cells caused by acute cold stress was inhibited by adrenalectomy or administration of a saturating amount of the GC antagonist RU 38486 (mifepristone). On the contrary, administration of the GC agonist, dexamethasone, markedly increased the proportion of FcγRIIbright cells in peritoneal exudate cells of control mice. These results suggest that the generation of FcγRIIbright suppressor cells of monocyte/macrophage lineage by acute cold stress was mediated by action of GC through the GC receptor. We likewise found that the proportion of FcγRIIbright suppressor macrophages is increased in aged mice (22–24 months of age). Meanwhile, activated macrophages which function as antigen presenting cells were decreased in aged rats. Both the basal corticosterone concentrations in serum and the expression of mRNA for GC receptor in peritoneal macrophages increased significantly in aged animals, suggesting that these populational and functional changes of macrophages in aged animals were mediated, in part, by the increased basal levels of GC. This is probably being responsible for immunosenescence.

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  1. Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2, Shinkawa, Mitaka, 181-8611, Tokyo, Japan

    Takako Kizaki, Kenji Suzuki & Hideki Ohno

  2. Department of Biochemistry, Hyogo University of Medicine, Hyogo

    Tomomi Ookawara & Keiichiro Suzuki

  3. Department of Kinesiology, Graduate School of Science, Tokyo Metroporitan University, Tokyo

    Tetsuya Izawa

  4. Department of Tramatology and Critical Care Medicine, National Defense Medical College, Saitama

    Daizoh Saitoh

  5. 5th Department of Internal Medicine, Tokyo Medical University, Tokyo

    Shuji Oh-Ishi

  6. Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki

    Shukoh Haga

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  1. Takako Kizaki
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  2. Kenji Suzuki
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Correspondence to Takako Kizaki.

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Kizaki, T., Suzuki, K., Ookawara, T. et al. Stress- and aging-associated modulation of macrophage functions. Environ Health Prev Med 6, 218 (2002). https://doi.org/10.1007/BF02897973

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Key words

  • macrophage
  • stress
  • aging
  • glucocorticoid
  • immunosuppression