Summary
Effects of Zaizhang-I (ZZ-I) on the recovery of hemopoietic systems from radiation injury were investigated. Mice, irradiated with 6. 0 Gy-rays, were injected i. p. once daily for 7 consecutive days with either ZZ-I or saline (0.01 ml/g body wt.). The experiments showed that ZZ-I significantly promoted the recovery of not only peripheral WBC. BMC, CFU-S and CFU-GM but also the abnormal femur micro-vessel system such as blood vessels and sinus ectasia, hyperemia and hemorrhage etc. These results suggest that ZZ-I could accelerate hemopoietic recovery from radiation injury in mice by stimulating hemopoietic stem cells and improving hemopoietic inductive microenvironment (HIM).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Till J E, McCulloch E A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Rad Res, 1961;14: 213
1985, 206
Millard R E. Radiosensitivity and recovery of two murine hemopoietic progenitor cell popular tion following Gamma rays and neutrons. Aeto Haemat, 1981; 66: 226
1978; 3587
1981; 12: 271
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ming-wei, Y., Mei-dong, H. & Ming-zhen, L. Effects of Zaizhang-I, a traditional chinese herbal medicine, on hematopoietic recovery from radiation injury in mice. Journal of Tongji Medical University 14, 224–226 (1994). https://doi.org/10.1007/BF02897673
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02897673