The amount of norepinephrine and dopamine in the brain of the mouse fed with normal diet or protein deficient diet with supplement of the saponin fraction of ginseng were determined by the fluorometric method. The amount of norepinephrine in mouse brain was increased by supplement of the saponin fraction of ginseng throughout the experimental period regardless of the kind of diet. However, the enhancing effect of the saponin fraction of ginseng on the level of norepinephrine in mouse brain was vivider in the case of protein deficiency. The increase amount of dopamine was observed only in the case of mouse fed with normal diet with supplement of the saponin fraction of ginseng for 8 weeks.
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Korean Ginseng Research Institute, Republic of Korea:Pharmacological actions of ginseng. pp. 46 (1978).
Takagi, K., Saito, H. and Nabata, H.: Pharmacological studies of Panax ginseng root.Japan J. Pharmacol. 22, 245 (1972).
Saito, H., Yoshida, Y., and Takagi, K.: Effect of Panax ginseng root on exhaustive in mice.Japan J. Pharmacol. 24, 119 (1974).
Takagi, K., Saito, H., and Tsuchiya, M.: Pharmacological properties of a crude saponin fraction.Japan J. Pharmacol. 22, 239 (1972).
Nabata, H., Saito, H. and Takagi, K.: Pharma cological studies of neutral saponin of Panax ginseng root.Japan J. Pharmacol. 23, 29 (1973).
Brekhman, I.I., and Dardymov, I.V.: New substance of plant origin which increase nonspecific resistance.Ann. Rev. Pharm. 9, 419 (1969).
Saito, H., Suda, K., Schwab, M. and Thoeneu, H.: Potentiation of the NGF-Mediated nerve fiber outgrowth by ginsenoside Rb1 in organ cultures of chicken dorsal root ganglia.Japan J. Pharmacol. 27, 445–451 (1977).
Kim, Y. and Kim, E.: Studies on the effect of ginseng extract on chicken embryonic nerve and muscle cells.Yakhak Hoeji. 24, 143–150 (1980).
Cooper, J.R., Bloom, F.E. and Roth, R.H.:The Biological Basis of Neuropharmacology pp. 102–195 Oxford University Press (1978).
Shoemaker, W.J. and Wurtman, R.J.: Effect of prenatal undernutrition on the metabolism of catecholamines in the rat brain.J. Nutr. 103, 1537 (1973).
Ahmad, Gulzar and Rahman, M.A.: Effect of undernutrition and protein malnutrition on brain chemistry of rats.J. Nutr. 105, 1090–1103 (1975).
Wurtman, R.J. and Fernstom, J.D.: Effect of the diet on brain neurotransmitters.Nutr. Rev. 32, 193 (1074).
Shoemaker, W.J. and Wurtman, R.J.: Prenatal undernutrition; Accumulation of catecholamines in rat brain.Science 171, 1017–1019 (1971).
Hrubes, V. and Benes, V.: Time course of metabolic changes during prolonged stress in rats.J. Psychosom Res. 13, 327 (1969).
Namba, T., Yoshizaki, M., Tomimori, T., Kobashi, K., Mitaui, K. and Hase, J.: Fundamental studies on the evaluation of the crude drugs. III Chemical and biochemical evaluation of ginseng and related crude drugs.Yakugaku Zasshi. 94, 252 (1974).
Ansell, G.B. and Beeson, M.F.: A rapid and sensitive procedure for the combined assay of adrenaline, dopamine and serotonin in a single brain sample.Anal. Biochem. 23, 196 (1968).
Shellenberger, M.K. and Gordon, J.H.: A rapid, simplified procedure for simultaneous assay of norepinephrine, dopamine, and serotonin from discrete brain areas.Anal. Biochem. 39, 350 (1971).
Martin, I.L. and Ansell, G.B.: Estimation of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain.Biochem. Pharm. 22, 521 (1973).
Sereni, F., Principi, N., Perletti, L. and Sereni, L.P.: Undernutrition and the developing rat brain.Biol. Neonat. 10, 254 (1966).
Dobbing, J.: The effect of undernutrition on myelination in the central nervous system.Biol. Neonat. 9, 132 (1966).
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Kim, Y.C., Lee, J.H., Kim, M.S. et al. Effect of the saponin fraction ofPanax ginseng on catecholamines in mouse brain. Arch. Pharm. Res. 8, 45–48 (1985). https://doi.org/10.1007/BF02897566
- Saponin fraction of ginseng
- Normal diet
- Protein deficient diet