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Antimicrobial and antineoplastic tyrosine metabolites from a marine sponge,Aplysina fistularis

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Abstract

Examination of the constituents of a marine sponge,Aplysina fistularis, indicated that brominated tyrosine metabolites were mainly responsible for antimicrobial and antineoplastic activities. Halogenated tyrosine metabolites, 2,6-dibromo-(2), 2-bromo-3-chloro-(3) and 2,6-dichloro-(4) 4-hydroxy-2, 5-cyclohexadienone-4-acetamides, as well as the lactam derivatives, 5-amino-2,6-dibromo-(5), 5-a mino-2-bromo-6-chloro-(6) and 5-amino-2,6-dichloro-(7) 4-hydroxy-2-cyclohexenone-4-acetic acid lactams were identified as the major antineoplastic and antimicrobial principles. Many other brominated tyrosine metabolites were also confirmed, but they did not show antimicrobial and antineoplastic activities.

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  1. College of Pharmacy, Seoul National University, Kwanakku, 151, Seoul, Korea

    Yang M. Goo

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  1. Yang M. Goo
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Goo, Y.M. Antimicrobial and antineoplastic tyrosine metabolites from a marine sponge,Aplysina fistularis . Arch. Pharm. Res. 8, 21–30 (1985). https://doi.org/10.1007/BF02897562

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  • DOI: https://doi.org/10.1007/BF02897562

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