Summary and Conclusions
One hundred and twenty-four patients with advanced or complicated stages of peptic ulcer disease have been treated for nine months with diphenmethanil methylsulfate as an adjunct to a restricted diet. One hundred and seventeen patients responded favorably to the drug. Gastrectomy and vagotomy were performed after medical therapy in7 patients with surgical indications. The ulcer had healed in all except one intractable patient. Five marginal ulcers healed without surgery. One hundred and six patients have remained asymptomatic. Eighty of these are healed radiographically, 14 show satisfactory but not yet complete healing, and 12 are yet to be examined.
Diphenmethanil methylsulfate is a distinctly useful adjunct to the management of peptic ulcer disease. Fewer undesirable side actions accompany the use of diphenmethanil methylsulfate than that of other effective anticholinergic drugs.
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Hoffmann, C.R. A clinical evaluation of diphenmethanil methylsulfate in the treatment of peptic ulcer disease. Amer. Jour. Dig. Dis. 20, 45–46 (1953). https://doi.org/10.1007/BF02897315
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DOI: https://doi.org/10.1007/BF02897315