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The effect of other Lipotropic substances on the fate of Choline after oral and intravenous administration

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The American Journal of Digestive Diseases

Summary and Conclusions

  1. 1.

    In vitro degradation of choline to trimethylamine (TMA) by fecal bacteria is unchanged in the presence of methionine, inositol, or both.

  2. 2.

    Rats fed methionine and inositol together with choline excreted the same amount of TMA in the urine as rats fed choline alone. Human experiments duplicated the experience in animals.

  3. 3.

    Humans excrete the same amount of choline in the urine following the intravenous injection of methionine, inositol and choline together as they do following the injection of choline alone.

  4. 4.

    The intravenous injection of methionine, inositol, and choline in relatively large amounts is well tolerated and appears to be without danger.

  5. 5.

    The presence of the lipotropic agents methionine and inositol does not appear to influence the degradation or excretion of choline after oral or intravenous administration, again pointing to the differences in the lipotropic action of these substances. We wish to thank Dr. Hans Popper for this generous advice during the conduct of tliis investigation.

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Supported by a grant from U. S. Vitamin Corporation, New York.

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Waldstein, S.S., Steigmann, F. The effect of other Lipotropic substances on the fate of Choline after oral and intravenous administration. Amer. Jour. Dig. Dis. 19, 323–325 (1952).

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