Summary
The S-100 protein was localized by immunocytochemistry in 70 pituitary tumors including 30 prolactin, 16 growth hormone, two corticotropin and 22 non-functioning adenomas. Positive immunostaining was observed in only one case (prolactin adenoma). It is concluded that in functioning and non-functioning pituitary tumors there is no particular involvement of S-100 protein-containing cells, at least under the conditions of this study.
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References
Girod C (1977) Apport de l’immunohistochimie à l’étude cytologique de l’adénohypophyse. Bull Assoc Anat 62:431–434
Girod C, Trouillas J, Dubois MP (1985) Immunocytochemical localization of S-100 protein in stellate cells (folliculo-stellate cells) of the anterior lobe of the normal human pituitary. Cell Tissue Res 241:505–511
Heshmati HM, Kujas M, Turpin G, Grémain J, Jacque CM, Racadot J (1985) Immunostaining of S-100 protein in the normal human pituitary gland. J Endocrinol Invest [Suppl 3]8:142 (Abstr)
Ishikawa H, Nogami H, Shirasawa N (1983) Novel clonal strains from adult rat anterior pituitary producing S-100 protein. Nature 303:711–713
Jacque CM, Kujas M, Poreau A, Raoul M, Collier P, Racadot J, Baumann N (1979) GFA and S-100 protein levels as an index for malignancy in human gliomas and neurinomas. J Natl Cancer Inst 62:479–483
Moore BW (1965) A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19:739–744
Moore BW, MacGregor D (1965) Chromatographic and electrophoretic fractionation of soluble proteins of brain and liver. J Biol Chem 240:1647–1653
Shirasawa N, Kihara H, Yamaguchi S, Yoshimura F (1983) Pituitary folliculo-stellate cells immunostained with S-100 protein antiserum in postnatal, castrated and thyroidectomized rats. Cell Tissue Res 231:235–249
Takahashi K, Isobe T, Ohtsuki Y, Akagi T, Sonobe H, Okuyama T (1984) Immunohistochemical study of the distribution of α and β of S-100 protein in human neoplasms and normal tissues. Virchows Arch [Cell Pathol] 45:385–396
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Turpin, G., Heshmati, H.M., Kujas, M. et al. Immunocytochemical study of S-100 protein in human pituitary adenomas. Virchows Archiv B Cell Pathol 55, 107–109 (1988). https://doi.org/10.1007/BF02896566
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DOI: https://doi.org/10.1007/BF02896566