Summary
To investigate the expression of vaginal IL-23 and its role in experimental murine vaginal candidiasis and its relationship with infection and immune status, immuno-competent (group A) and immuno-suppressed (group B) murine models of vaginal candidiasis were established in estrogen-treated mice. Non-estrogen-treated mice were used as controls (group C). The level of IL-23 p19 mRNA in murine vaginal tissue was determined by RT-PCR. Significantly increased levels of IL-23p19mRNA were observed on the 4th, the 7th and 14th day after inoculation in immuno-competent group when compared with that in control group (P<0.01,P<0.05), However, significant increase of IL-23 p19mRNA were only observed on the 7th day and the 14th day after inoculatuon in immuno-suppressed groups (P<0.05). On the 4th and 7th day, the levels of Il-23 p19mRNA were significantly increased in immuno-competent group, than those in immuno-suppressed group (P<0.05). Local IL-23 may play a role in the pathogenesis of murine vaginal candidiasis and has a protective function during infection. Low vaginal IL-23 level may correlate with the increased susceptibility toCandida albicans in immuno-suppressed group.
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WU Yan, female, born in 1975, Doctor in Charge
This project was supported by grants from the Science Research Foundation of Health Department of Hubei Province (No. JXIB048) and the Janssen Research Foundation.
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Yan, W., Zhijian, T., Zhixiang, L. et al. Local IL-23 expression in murine vaginal candidiasis and its relationship with infection and immune status. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 26, 245–247 (2006). https://doi.org/10.1007/BF02895828
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DOI: https://doi.org/10.1007/BF02895828