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P53 gene mutations in non-Hodgkin’s lymphoma

Journal of Tongji Medical University volume 19, pages 27–30 (1999)Cite this article

Summary

To understand P53 gene change of non-Hodgkin’s lymphoma (NHL) and human malignant lymphoma cell lines, the exons 5–7 of 29 patients with NHL and 9 kinds of human malignant lymphoma cell lines were studied by silver staining PCR-SSCP technique. Three cases of P53 gene point mutation was found in 29 cases of NHL. Mutation developed in exon 5 in 2 cases, and in exon 6 in 1 case. They were all diffuse lymphoma. In mutation cases, B-cell lymphoma accounted for 2 cases and the other one was T-cell lymphoma. There was no P53 gene mutation in low-grade follicular lymphoma. Seven strains out of 9 kinds of lymphoma cell lines had P53 gene point mutation. One strain had the mutation in exon 5; 5 strains in exon 6 and 1 strain in exons 5, 6, 7. There was a high mutation rate in lymphoma cell lines and low mutation rate in NHL patients. P53 gene plays an important role in lymphoma cell line establishment, cell regeneration and disease evolution.

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Affiliations

  1. Professor, Institute of Hematology, Xiehe Hospital, Tongji Medical University, 430022, Wuhan

    Chen Yan, Xiang Zhifu, Li Huiyu, Yang Nianlan & Zhang Hongyu

Authors
  1. Chen Yan
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  2. Xiang Zhifu
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  3. Li Huiyu
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  4. Yang Nianlan
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  5. Zhang Hongyu
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Additional information

This project was supported by national initiative programs for scholars coming back from other countries (No. 95–135).

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Yan, C., Zhifu, X., Huiyu, L. et al. P53 gene mutations in non-Hodgkin’s lymphoma. Journal of Tongji Medical University 19, 27–30 (1999). https://doi.org/10.1007/BF02895589

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  • DOI: https://doi.org/10.1007/BF02895589

Key words

  • non-Hodgkin’s lymphoma
  • P53 gene mutation