Annals of Behavioral Medicine

, Volume 18, Issue 4, pp 255–263 | Cite as

Effect of stress on opioid-seeking behavior: Evidence from studies with rats

  • Yavin Shaham
Empirical Research


Studies concerned with the relation between exposure to stress and the behavioral effects of opioid agonists in animal models of drug use are reviewed. These studies, which primarily utilized male rats, indicate that under certain conditions short-term mild stressors increase self-administration of opioid drugs and reinstate herein-seeking behavior following a drugfree period. On the other hand, there is evidence that long-term chronic inescapable stressors and severe acute stressors reduce the reinforcing effects of morphine as measured by a conditioned place preference procedure and decrease the behavioral effects of other positive reinforcers. The results of the studies reviewed suggest that stressors are important modulators of opioid-taking behavior, especially during drug-free periods. The implications of these findings to the understanding of the neurobiology of relapse to opioid-seeking behavior and for strategies for medication development to prevent relapse to heroin are discussed.


Morphine Heroin Chronic Mild Stress Opioid Drug Footshock Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Society of Behavioral Medicine 1996

Authors and Affiliations

  • Yavin Shaham
    • 1
  1. 1.Biobehavioral Research DepartmentAddiction Research FoundationTorontoCanada

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